Abstract
Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
Original language | English (US) |
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Article number | e983393 |
Journal | Molecular and Cellular Oncology |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - Jul 3 2015 |
Externally published | Yes |
Keywords
- BRCA1
- SAT1
- glioblastoma
- histone acetylation
- radiation resistance
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research