SAT1 and glioblastoma multiforme: Disarming the resistance

Adina Brett-Morris; Mazen Mislmani; Scott M. Welford

doi:10.4161/23723556.2014.983393

SAT1 and glioblastoma multiforme: Disarming the resistance

Adina Brett-Morris, Mazen Mislmani, Scott M. Welford

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.

Original language	English (US)
Article number	e983393
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.983393
State	Published - Jul 3 2015
Externally published	Yes

Keywords

BRCA1
SAT1
glioblastoma
histone acetylation
radiation resistance

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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