SAT1 and glioblastoma multiforme: Disarming the resistance

Adina Brett-Morris, Mazen Mislmani, Scott M. Welford

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.

Original languageEnglish (US)
Article numbere983393
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015

Keywords

  • BRCA1
  • SAT1
  • glioblastoma
  • histone acetylation
  • radiation resistance

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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