SAT1 and glioblastoma multiforme: Disarming the resistance

Adina Brett-Morris, Mazen Mislmani, Scott Welford

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.

Original languageEnglish (US)
Article numbere983393
JournalMolecular and Cellular Oncology
Volume2
Issue number3
DOIs
StatePublished - Jul 3 2015
Externally publishedYes

Fingerprint

Spermine
Polyamines
Glioblastoma
Brain Neoplasms
DNA Repair
Chromatin
Enzymes
Therapeutics
diamine N-acetyltransferase

Keywords

  • BRCA1
  • glioblastoma
  • histone acetylation
  • radiation resistance
  • SAT1

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

Cite this

SAT1 and glioblastoma multiforme : Disarming the resistance. / Brett-Morris, Adina; Mislmani, Mazen; Welford, Scott.

In: Molecular and Cellular Oncology, Vol. 2, No. 3, e983393, 03.07.2015.

Research output: Contribution to journalArticle

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