Abstract
Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
| Original language | English (US) |
|---|---|
| Article number | e983393 |
| Journal | Molecular and Cellular Oncology |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 3 2015 |
| Externally published | Yes |
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Keywords
- BRCA1
- glioblastoma
- histone acetylation
- radiation resistance
- SAT1
ASJC Scopus subject areas
- Cancer Research
- Molecular Medicine
Cite this
SAT1 and glioblastoma multiforme : Disarming the resistance. / Brett-Morris, Adina; Mislmani, Mazen; Welford, Scott.
In: Molecular and Cellular Oncology, Vol. 2, No. 3, e983393, 03.07.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SAT1 and glioblastoma multiforme
T2 - Disarming the resistance
AU - Brett-Morris, Adina
AU - Mislmani, Mazen
AU - Welford, Scott
PY - 2015/7/3
Y1 - 2015/7/3
N2 - Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
AB - Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
KW - BRCA1
KW - glioblastoma
KW - histone acetylation
KW - radiation resistance
KW - SAT1
UR - http://www.scopus.com/inward/record.url?scp=85041191955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041191955&partnerID=8YFLogxK
U2 - 10.4161/23723556.2014.983393
DO - 10.4161/23723556.2014.983393
M3 - Article
AN - SCOPUS:85041191955
VL - 2
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 3
M1 - e983393
ER -