SAT1 and glioblastoma multiforme: Disarming the resistance

Adina Brett-Morris; Mazen Mislmani; Scott M. Welford

doi:10.4161/23723556.2014.983393

SAT1 and glioblastoma multiforme: Disarming the resistance

Adina Brett-Morris, Mazen Mislmani, Scott M. Welford

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.

Original language	English (US)
Article number	e983393
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.983393
State	Published - Jul 3 2015
Externally published	Yes

Keywords

BRCA1
SAT1
glioblastoma
histone acetylation
radiation resistance

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/23723556.2014.983393

Cite this

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abstract = "Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.",

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AB - Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.

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KW - histone acetylation

KW - radiation resistance

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SAT1 and glioblastoma multiforme: Disarming the resistance

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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