SARS-CoV-2 in the Prostate: Immunohistochemical and Ultrastructural Studies

Rohit Reddy, Natoli Farber, Eliyahu Kresch, Deepa Seetharam, Parris Diaz, Ranjith Ramasamy

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The novel coronavirus SARS-CoV-2 was discovered in 2019 and has proven to be a significant public health challenge. While viruses from the coronavirus family have been established as causes of respiratory tract infections, SARS-CoV-2 has also been found in the heart, kidney, testes, and penis. This paper investigates whether SARS-CoV-2 can linger in the prostate by examining the histopathological, ultrastructural, and immunofluorescent elements of prostatic tissue from a patient who was infected by the SARS-CoV-2 virus prior to having a holmium laser enucleation of the prostate (HoLEP) procedure. The findings of this case report suggest that COVID-19 has both the ability to enter prostatic tissue during an acute infection and persist over a timeframe beyond the initial infection period as RNA-containing viral bodies. This case report lays the foundation for future investigations to examine any histopathological changes to the prostatic tissue that may be associated with SARS-CoV-2 viral infection.

Original languageEnglish (US)
Article numberA7
JournalWorld Journal of Men?s Health
Volume40
DOIs
StatePublished - 2022
Externally publishedYes

Keywords

  • COVID-19
  • Microscopy, electron
  • Prostate
  • Prostatic hyperplasia
  • SARS-CoV-2

ASJC Scopus subject areas

  • Aging
  • Reproductive Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Urology
  • Pharmacology (medical)

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