SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

HPAP Consortium

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Coate et al. examined expression of canonical SARS-CoV-2 entry proteins ACE2 and TMPRSS2 in the human pancreas and report ACE2 expression in the microvasculature, including islet pericytes, whereas both ACE2 and TMPRSS2 are expressed in some ducts. Conversely, neither protein is detected in β cells, arguing against direct β cell viral infection in vivo.

Original languageEnglish (US)
Pages (from-to)1028-1040.e4
JournalCell Metabolism
Volume32
Issue number6
DOIs
StatePublished - Dec 1 2020

Keywords

  • ACE2
  • COVID-19
  • SARS-CoV-2
  • TMPRSS2
  • beta cell
  • duct
  • islet
  • microvasculature
  • pancreas
  • pericyte

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells'. Together they form a unique fingerprint.

Cite this