Sampling of radical prostatectomy specimens: How much is adequate?

M. B. Cohen, M. S. Soloway, W. M. Murphy

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Prostate glands from 52 patients with clinical stage B carcinoma were examined using two sampling techniques. After fixation and conization of the apical portions, each gland was serially sectioned with sections mounted whole on oversized glass slides and examined for pathologic features of prognostic importance. A second examination was subsequently conducted on the same tissue using only alternate sections. No differences in tumor type, grade, Gleason score, multiplicity, or capsular penetration were detected in 75% of cases. The discrepancies that did occur were most often minor variations in multiplicity and Gleason score. Of the 20 glands with capsular penetration observed with the serial sectioning method, 17 (85%) were detected using alternate sectioning. The surgical margin was involved in two of the three invasive foci that would have been missed. Although the topography is better displayed, the authors' examinations indicated no significant advantage to whole mount sections compared with sections mounted on standard-sized glass slides. Considering the most effective use of resources, as well as the current modalities available for patient monitoring, the results support the use of an alternate sectioning method for pathologic examination of specimens removed for clinically localized prostate cancer.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalAmerican Journal of Clinical Pathology
Volume101
Issue number3
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Neoplasm Grading
Prostatectomy
Glass
Conization
Physiologic Monitoring
Prostate
Prostatic Neoplasms
Carcinoma
Neoplasms
Margins of Excision

Keywords

  • Prognostic factors
  • Prostate cancer
  • Tissue sampling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cohen, M. B., Soloway, M. S., & Murphy, W. M. (1994). Sampling of radical prostatectomy specimens: How much is adequate? American Journal of Clinical Pathology, 101(3), 250-252.

Sampling of radical prostatectomy specimens : How much is adequate? / Cohen, M. B.; Soloway, M. S.; Murphy, W. M.

In: American Journal of Clinical Pathology, Vol. 101, No. 3, 01.01.1994, p. 250-252.

Research output: Contribution to journalArticle

Cohen, MB, Soloway, MS & Murphy, WM 1994, 'Sampling of radical prostatectomy specimens: How much is adequate?', American Journal of Clinical Pathology, vol. 101, no. 3, pp. 250-252.
Cohen, M. B. ; Soloway, M. S. ; Murphy, W. M. / Sampling of radical prostatectomy specimens : How much is adequate?. In: American Journal of Clinical Pathology. 1994 ; Vol. 101, No. 3. pp. 250-252.
@article{f7ab74b66aab49a6b9c85fd0a807d6e7,
title = "Sampling of radical prostatectomy specimens: How much is adequate?",
abstract = "Prostate glands from 52 patients with clinical stage B carcinoma were examined using two sampling techniques. After fixation and conization of the apical portions, each gland was serially sectioned with sections mounted whole on oversized glass slides and examined for pathologic features of prognostic importance. A second examination was subsequently conducted on the same tissue using only alternate sections. No differences in tumor type, grade, Gleason score, multiplicity, or capsular penetration were detected in 75{\%} of cases. The discrepancies that did occur were most often minor variations in multiplicity and Gleason score. Of the 20 glands with capsular penetration observed with the serial sectioning method, 17 (85{\%}) were detected using alternate sectioning. The surgical margin was involved in two of the three invasive foci that would have been missed. Although the topography is better displayed, the authors' examinations indicated no significant advantage to whole mount sections compared with sections mounted on standard-sized glass slides. Considering the most effective use of resources, as well as the current modalities available for patient monitoring, the results support the use of an alternate sectioning method for pathologic examination of specimens removed for clinically localized prostate cancer.",
keywords = "Prognostic factors, Prostate cancer, Tissue sampling",
author = "Cohen, {M. B.} and Soloway, {M. S.} and Murphy, {W. M.}",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "101",
pages = "250--252",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "3",

}

TY - JOUR

T1 - Sampling of radical prostatectomy specimens

T2 - How much is adequate?

AU - Cohen, M. B.

AU - Soloway, M. S.

AU - Murphy, W. M.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Prostate glands from 52 patients with clinical stage B carcinoma were examined using two sampling techniques. After fixation and conization of the apical portions, each gland was serially sectioned with sections mounted whole on oversized glass slides and examined for pathologic features of prognostic importance. A second examination was subsequently conducted on the same tissue using only alternate sections. No differences in tumor type, grade, Gleason score, multiplicity, or capsular penetration were detected in 75% of cases. The discrepancies that did occur were most often minor variations in multiplicity and Gleason score. Of the 20 glands with capsular penetration observed with the serial sectioning method, 17 (85%) were detected using alternate sectioning. The surgical margin was involved in two of the three invasive foci that would have been missed. Although the topography is better displayed, the authors' examinations indicated no significant advantage to whole mount sections compared with sections mounted on standard-sized glass slides. Considering the most effective use of resources, as well as the current modalities available for patient monitoring, the results support the use of an alternate sectioning method for pathologic examination of specimens removed for clinically localized prostate cancer.

AB - Prostate glands from 52 patients with clinical stage B carcinoma were examined using two sampling techniques. After fixation and conization of the apical portions, each gland was serially sectioned with sections mounted whole on oversized glass slides and examined for pathologic features of prognostic importance. A second examination was subsequently conducted on the same tissue using only alternate sections. No differences in tumor type, grade, Gleason score, multiplicity, or capsular penetration were detected in 75% of cases. The discrepancies that did occur were most often minor variations in multiplicity and Gleason score. Of the 20 glands with capsular penetration observed with the serial sectioning method, 17 (85%) were detected using alternate sectioning. The surgical margin was involved in two of the three invasive foci that would have been missed. Although the topography is better displayed, the authors' examinations indicated no significant advantage to whole mount sections compared with sections mounted on standard-sized glass slides. Considering the most effective use of resources, as well as the current modalities available for patient monitoring, the results support the use of an alternate sectioning method for pathologic examination of specimens removed for clinically localized prostate cancer.

KW - Prognostic factors

KW - Prostate cancer

KW - Tissue sampling

UR - http://www.scopus.com/inward/record.url?scp=0028231732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028231732&partnerID=8YFLogxK

M3 - Article

C2 - 8135177

AN - SCOPUS:0028231732

VL - 101

SP - 250

EP - 252

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 3

ER -