TY - JOUR

T1 - Sample size to test for interaction between a specific exposure and a second risk factor in a pair-matched case-control study

AU - Qiu, Peihua

AU - Moeschberger, Melvin L.

AU - Cooke, Glen E.

AU - Goldschmidt-Clermont, Pascal J.

PY - 2000/4/15

Y1 - 2000/4/15

N2 - We discuss a sample size calculation for a pair-matched case-control study to test for interaction between a specific exposure and a second risk factor. The second risk factor could be either binary or continuous. An algorithm for the calculation of sample size is suggested which is based on a logistic regression model that relates the logarithm of the disease-exposure odds ratio to the second risk factor. This problem is motivated by a study comparing the prevalence of GP-IIIa Pl(A2) polymorphism (the exposure) in individuals with and without myocardial infarction (case-control). One of the hypotheses in this study is whether or not there is an interaction between the prevalence of GP-IIIa Pl(A2) polymorphism and a second risk factor such as smoking status and homocysteine level. We introduce the algorithm in detail with several numerical examples. (C) 2000 John Wiley and Sons, Ltd.

AB - We discuss a sample size calculation for a pair-matched case-control study to test for interaction between a specific exposure and a second risk factor. The second risk factor could be either binary or continuous. An algorithm for the calculation of sample size is suggested which is based on a logistic regression model that relates the logarithm of the disease-exposure odds ratio to the second risk factor. This problem is motivated by a study comparing the prevalence of GP-IIIa Pl(A2) polymorphism (the exposure) in individuals with and without myocardial infarction (case-control). One of the hypotheses in this study is whether or not there is an interaction between the prevalence of GP-IIIa Pl(A2) polymorphism and a second risk factor such as smoking status and homocysteine level. We introduce the algorithm in detail with several numerical examples. (C) 2000 John Wiley and Sons, Ltd.

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U2 - 10.1002/(SICI)1097-0258(20000415)19:7<923::AID-SIM341>3.0.CO;2-O

DO - 10.1002/(SICI)1097-0258(20000415)19:7<923::AID-SIM341>3.0.CO;2-O

M3 - Article

C2 - 10750060

AN - SCOPUS:0034655569

VL - 19

SP - 923

EP - 935

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 0277-6715

IS - 7

ER -