Sample bias among women with retained DNA samples for future genetic studies

Kjersti Aagaard-Tillery, Baha Sibai, Catherine Y. Spong, Valerija Momirova, George Wendel, Katharine Wenstrom, Philip Samuels, Margaret Cotroneo, Atef Moawad, Yoram Sorokin, Menachem Miodovnik, Paul Meis, Mary J. O'Sullivan, Deborah Conway, Ronald J. Wapner

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate whether women who agree to future use of their biologic specimens for genetic studies reflect the larger study population from which they are derived. METHODS: Women were questioned as to the future disposition of their maternal and fetal DNA samples upon enrollment in a multicenter, observational study originally designed to identify factor V Leiden mutation carriers and prospectively ascertain the estimated rate of pregnancy-related venous thromboembolism and adverse pregnancy outcome. Univariate and multivariate analyses was carried out on the 5,003 of 5,188 enrolled women who indicated their desire regarding future disposition of their DNA samples. RESULTS: Among these 5,003 women, 20.1% desired that their samples be discarded and not available for future genetic studies. Multivariate analysis demonstrated that women who agreed to subsequent use of samples were less likely African-American (odds ratio [OR] 0.6, 95% confidence interval [CI] 0.4-0.7) or Hispanic (OR 0.4, 95% CI 0.3-0.5), and more likely to use tobacco (OR 1.2, 95% CI 1.0-1.6) than those who desired that their samples be discarded. CONCLUSION: Genetic samples from women agreeing to their use in a sample repository may not be representative of the index study cohort. This should be considered in their subsequent interpretation and generalizability.

Original languageEnglish
Pages (from-to)1115-1120
Number of pages6
JournalObstetrics and Gynecology
Volume108
Issue number5
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

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DNA
Odds Ratio
Confidence Intervals
Multivariate Analysis
Venous Thromboembolism
Tobacco Use
Pregnancy Rate
Pregnancy Outcome
Hispanic Americans
African Americans
Multicenter Studies
Observational Studies
Cohort Studies
Mothers
Mutation
Population

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Aagaard-Tillery, K., Sibai, B., Spong, C. Y., Momirova, V., Wendel, G., Wenstrom, K., ... Wapner, R. J. (2006). Sample bias among women with retained DNA samples for future genetic studies. Obstetrics and Gynecology, 108(5), 1115-1120. https://doi.org/10.1097/01.AOG.0000241536.19539.14

Sample bias among women with retained DNA samples for future genetic studies. / Aagaard-Tillery, Kjersti; Sibai, Baha; Spong, Catherine Y.; Momirova, Valerija; Wendel, George; Wenstrom, Katharine; Samuels, Philip; Cotroneo, Margaret; Moawad, Atef; Sorokin, Yoram; Miodovnik, Menachem; Meis, Paul; O'Sullivan, Mary J.; Conway, Deborah; Wapner, Ronald J.

In: Obstetrics and Gynecology, Vol. 108, No. 5, 01.11.2006, p. 1115-1120.

Research output: Contribution to journalArticle

Aagaard-Tillery, K, Sibai, B, Spong, CY, Momirova, V, Wendel, G, Wenstrom, K, Samuels, P, Cotroneo, M, Moawad, A, Sorokin, Y, Miodovnik, M, Meis, P, O'Sullivan, MJ, Conway, D & Wapner, RJ 2006, 'Sample bias among women with retained DNA samples for future genetic studies', Obstetrics and Gynecology, vol. 108, no. 5, pp. 1115-1120. https://doi.org/10.1097/01.AOG.0000241536.19539.14
Aagaard-Tillery K, Sibai B, Spong CY, Momirova V, Wendel G, Wenstrom K et al. Sample bias among women with retained DNA samples for future genetic studies. Obstetrics and Gynecology. 2006 Nov 1;108(5):1115-1120. https://doi.org/10.1097/01.AOG.0000241536.19539.14
Aagaard-Tillery, Kjersti ; Sibai, Baha ; Spong, Catherine Y. ; Momirova, Valerija ; Wendel, George ; Wenstrom, Katharine ; Samuels, Philip ; Cotroneo, Margaret ; Moawad, Atef ; Sorokin, Yoram ; Miodovnik, Menachem ; Meis, Paul ; O'Sullivan, Mary J. ; Conway, Deborah ; Wapner, Ronald J. / Sample bias among women with retained DNA samples for future genetic studies. In: Obstetrics and Gynecology. 2006 ; Vol. 108, No. 5. pp. 1115-1120.
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AU - Spong, Catherine Y.

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AU - Wendel, George

AU - Wenstrom, Katharine

AU - Samuels, Philip

AU - Cotroneo, Margaret

AU - Moawad, Atef

AU - Sorokin, Yoram

AU - Miodovnik, Menachem

AU - Meis, Paul

AU - O'Sullivan, Mary J.

AU - Conway, Deborah

AU - Wapner, Ronald J.

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N2 - OBJECTIVE: To evaluate whether women who agree to future use of their biologic specimens for genetic studies reflect the larger study population from which they are derived. METHODS: Women were questioned as to the future disposition of their maternal and fetal DNA samples upon enrollment in a multicenter, observational study originally designed to identify factor V Leiden mutation carriers and prospectively ascertain the estimated rate of pregnancy-related venous thromboembolism and adverse pregnancy outcome. Univariate and multivariate analyses was carried out on the 5,003 of 5,188 enrolled women who indicated their desire regarding future disposition of their DNA samples. RESULTS: Among these 5,003 women, 20.1% desired that their samples be discarded and not available for future genetic studies. Multivariate analysis demonstrated that women who agreed to subsequent use of samples were less likely African-American (odds ratio [OR] 0.6, 95% confidence interval [CI] 0.4-0.7) or Hispanic (OR 0.4, 95% CI 0.3-0.5), and more likely to use tobacco (OR 1.2, 95% CI 1.0-1.6) than those who desired that their samples be discarded. CONCLUSION: Genetic samples from women agreeing to their use in a sample repository may not be representative of the index study cohort. This should be considered in their subsequent interpretation and generalizability.

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