Salt sensitivity and hypertension after menopause

Role of nitric oxide and angiotensin II

Ivonne H Schulman, Leopoldo Raij

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Hypertension is a major risk factor for cardiovascular disease and renal disease. After menopause, the incidence of hypertension increases in women to levels that equal or exceed that in men, suggesting a protective role of female sex hormones. Salt sensitivity of blood pressure is associated with an increased risk for development of hypertension and cardiovascular disease. We and others have demonstrated that after menopause, the prevalence of salt sensitivity increases, suggesting that female sex hormones influence renal sodium handling and blood pressure regulation. A homeostatic balance between the counteracting effects of nitric oxide (NO) and angiotensin (Ang) II on pressure natriuresis, renal hemodynamics, tubular sodium reabsorption, and oxidative stress plays an important role in modulating salt sensitivity as well as hypertensive end-organ injury. Estrogens modulate the activity and expression of NO and Ang II. We infer that after menopause, estrogen deficiency promotes an unbalance between NO and Ang II, resulting in disturbed renal sodium handling, oxidative stress, and hypertension, particularly in genetically prone women. A better understanding of the mechanisms underlying the development of postmenopausal hypertension and associated cardiovascular and renal diseases should provide insights into preventive and therapeutic strategies.

Original languageEnglish
Pages (from-to)170-180
Number of pages11
JournalAmerican Journal of Nephrology
Volume26
Issue number2
DOIs
StatePublished - May 1 2006

Fingerprint

Menopause
Angiotensin II
Nitric Oxide
Salts
Hypertension
Kidney
Cardiovascular Diseases
Sodium
Gonadal Steroid Hormones
Estrogens
Oxidative Stress
Blood Pressure
Natriuresis
Hemodynamics
Pressure
Incidence
Wounds and Injuries
Therapeutics

Keywords

  • Angiotensin II
  • Estrogen
  • Hypertension
  • Nitric oxide
  • Sodium

ASJC Scopus subject areas

  • Nephrology

Cite this

Salt sensitivity and hypertension after menopause : Role of nitric oxide and angiotensin II. / Schulman, Ivonne H; Raij, Leopoldo.

In: American Journal of Nephrology, Vol. 26, No. 2, 01.05.2006, p. 170-180.

Research output: Contribution to journalArticle

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