Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension

Vito M. Campese, Medhat Tawadrous, Roberto Bigazzi, Stefano Bianchi, Amardeep S. Mann, Suzanne Oparil, Leopoldo Raij

Research output: Contribution to journalArticle

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Abstract

In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO2+NO3 in 7 normotensive individuals and 13 salt- sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive whites during low and high salt intakes. Under low salt conditions, plasma ANP levels were not different in normotensive control subjects and salt-sensitive and salt-resistant hypertensive blacks. During high salt intake, plasma ANP levels did not change in control subjects and salt-resistant patients but decreased in salt- sensitive patients. ANP levels after high salt diet were lower (P<.01) in salt-sensitive than salt-resistant blacks. In hypertensive whites, high salt intake caused no significant change in plasma ANP. Under low salt conditions, plasma NO2±NO3 levels were higher (P<.05) in salt-sensitive (189±7.9 μmol/L) and salt-resistant (195±13.5 μmol/L) black patients than in control subjects (108±9.7 μmol/L). During high salt intake, plasma NO2±NO3 decreased significantly (P<.01) in both salt-sensitive (150±7.0 μmol/L) and salt-resistant (142±9.0 μmol/L) patients. These studies show that under conditions of high salt intake, salt-sensitive hypertensive blacks manifest a paradoxical decrease in ANP secretion. This abnormality may play a role in the reduced ability of these individuals to excrete a sodium load and in the sodium-induced rise in blood pressure. This study does not support the hypothesis that salt sensitivity depends on a deficit of nitric oxide production, but it suggests that high salt intake may alter the endothelium- dependent adaptation of peripheral resistance vessels.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalHypertension
Volume28
Issue number3
StatePublished - Sep 1 1996
Externally publishedYes

Fingerprint

Atrial Natriuretic Factor
Nitric Oxide
Salts
Hypertension
Sodium

Keywords

  • blacks
  • hypertension, sodium- dependent
  • natriuretic peptides
  • nitric oxide
  • sodium, dietary endothelium-derived factor

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Campese, V. M., Tawadrous, M., Bigazzi, R., Bianchi, S., Mann, A. S., Oparil, S., & Raij, L. (1996). Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension. Hypertension, 28(3), 335-340.

Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension. / Campese, Vito M.; Tawadrous, Medhat; Bigazzi, Roberto; Bianchi, Stefano; Mann, Amardeep S.; Oparil, Suzanne; Raij, Leopoldo.

In: Hypertension, Vol. 28, No. 3, 01.09.1996, p. 335-340.

Research output: Contribution to journalArticle

Campese, VM, Tawadrous, M, Bigazzi, R, Bianchi, S, Mann, AS, Oparil, S & Raij, L 1996, 'Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension', Hypertension, vol. 28, no. 3, pp. 335-340.
Campese VM, Tawadrous M, Bigazzi R, Bianchi S, Mann AS, Oparil S et al. Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension. Hypertension. 1996 Sep 1;28(3):335-340.
Campese, Vito M. ; Tawadrous, Medhat ; Bigazzi, Roberto ; Bianchi, Stefano ; Mann, Amardeep S. ; Oparil, Suzanne ; Raij, Leopoldo. / Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension. In: Hypertension. 1996 ; Vol. 28, No. 3. pp. 335-340.
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