Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore

Richard S. Hutehins, Preeti Bansal, Pedro Molina, Mateo Alajarín, Angel Vidal, Leonidas G Bachas

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

A biomimetic strategy was employed in the development of oxoanion-selective ionophores containing the guanidinium functional group. These ionophores mimic the selective interaction observed between arginine residues of proteins and oxoanions. In previous work, it was demonstrated that a structurally rigid guanidinium ionophore exhibited excellent hydrogen sulfite selectivity (Anal. Chem. 1994, 66, 3188-3192). Herein, we describe guanidinium-containing ionophores that are selective for the oxoanion salicylate. The ability to rationally design anion-selective electrodes through this biomimetic strategy, and to both alter selectivity and improve response characteristics through structural changes to the ionophore, has been demonstrated. 1H-NMR complexation and modeling studies were used to examine and correlate the selectivity observed with the structure of the guanidinium compounds.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalAnalytical Chemistry
Volume69
Issue number7
StatePublished - 1997
Externally publishedYes

Fingerprint

Salicylates
Ionophores
Guanidine
Biomimetics
Electrodes
Complexation
Functional groups
Anions
Arginine
Nuclear magnetic resonance
Proteins

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Hutehins, R. S., Bansal, P., Molina, P., Alajarín, M., Vidal, A., & Bachas, L. G. (1997). Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore. Analytical Chemistry, 69(7), 1273-1278.

Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore. / Hutehins, Richard S.; Bansal, Preeti; Molina, Pedro; Alajarín, Mateo; Vidal, Angel; Bachas, Leonidas G.

In: Analytical Chemistry, Vol. 69, No. 7, 1997, p. 1273-1278.

Research output: Contribution to journalArticle

Hutehins, RS, Bansal, P, Molina, P, Alajarín, M, Vidal, A & Bachas, LG 1997, 'Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore', Analytical Chemistry, vol. 69, no. 7, pp. 1273-1278.
Hutehins RS, Bansal P, Molina P, Alajarín M, Vidal A, Bachas LG. Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore. Analytical Chemistry. 1997;69(7):1273-1278.
Hutehins, Richard S. ; Bansal, Preeti ; Molina, Pedro ; Alajarín, Mateo ; Vidal, Angel ; Bachas, Leonidas G. / Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore. In: Analytical Chemistry. 1997 ; Vol. 69, No. 7. pp. 1273-1278.
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