Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore

Richard S. Hutehins, Preeti Bansal, Pedro Molina, Mateo Alajarín, Angel Vidal, Laonidas G. Bachas

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Abstract

A biomimetic strategy was employed in the development of oxoanion-selective ionophores containing the guanidinium functional group. These ionophores mimic the selective interaction observed between arginine residues of proteins and oxoanions. In previous work, it was demonstrated that a structurally rigid guanidinium ionophore exhibited excellent hydrogen sulfite selectivity (Anal. Chem. 1994, 66, 3188-3192). Herein, we describe guanidinium-containing ionophores that are selective for the oxoanion salicylate. The ability to rationally design anion-selective electrodes through this biomimetic strategy, and to both alter selectivity and improve response characteristics through structural changes to the ionophore, has been demonstrated. 1H-NMR complexation and modeling studies were used to examine and correlate the selectivity observed with the structure of the guanidinium compounds.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalAnalytical Chemistry
Volume69
Issue number7
StatePublished - Dec 1 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Hutehins, R. S., Bansal, P., Molina, P., Alajarín, M., Vidal, A., & Bachas, L. G. (1997). Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore. Analytical Chemistry, 69(7), 1273-1278.