Salicylate-Selective Electrode Based on a Biomimetic Guanidinium lonophore

Richard S. Hutehins, Preeti Bansal, Pedro Molina, Mateo Alajarín, Angel Vidal, Laonidas G. Bachas

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

A biomimetic strategy was employed in the development of oxoanion-selective ionophores containing the guanidinium functional group. These ionophores mimic the selective interaction observed between arginine residues of proteins and oxoanions. In previous work, it was demonstrated that a structurally rigid guanidinium ionophore exhibited excellent hydrogen sulfite selectivity (Anal. Chem. 1994, 66, 3188-3192). Herein, we describe guanidinium-containing ionophores that are selective for the oxoanion salicylate. The ability to rationally design anion-selective electrodes through this biomimetic strategy, and to both alter selectivity and improve response characteristics through structural changes to the ionophore, has been demonstrated. 1H-NMR complexation and modeling studies were used to examine and correlate the selectivity observed with the structure of the guanidinium compounds.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalAnalytical Chemistry
Volume69
Issue number7
DOIs
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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