Safety of the blood supply: Role of pathogen reduction

Yan Yun Wu, Edward L. Snyder

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Even though the blood supply is very safe, the risk of transfusion transmitted disease is not zero. To improve the safety of the blood supply, pathogen reduction (PR) technology has been developed. The principle of most current PR strategies involves modifying DNA or RNA templates and making them inaccessible to DNA or RNA polymerase. Several platforms of pathogen reduction are available including psoralens, alkylating compounds, binary ethyleneimine-like compounds, riboflavin, methylene blue, and solvent-detergent treatment. PR systems have been designed for RBC, plasma, and platelets. PR technology has been found to be effective for a variety of pathogens including lipid-enveloped and non-enveloped viruses, bacteria and parasites. Pre-clinical studies and Phase III clinical trials to evaluate the efficacy and safety of these PR technologies are currently ongoing.

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalBlood Reviews
Volume17
Issue number2
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Alkylating compounds
  • Binary ethyleneimine-like compounds
  • Blood supply safety
  • Methylene blue
  • Pathogen inactivation
  • Pathogen reduction
  • Psoralens
  • Riboflavin
  • Solvent-detergent treatment

ASJC Scopus subject areas

  • Hematology
  • Oncology

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