Safety of tenofovir use during pregnancy: Early growth outcomes in HIV-exposed uninfected infants

George K. Siberry, Paige L. Williams, Hermann Mendez, George R. Seage, Denise L. Jacobson, Rohan Hazra, Kenneth C. Rich, Raymond Griner, Katherine Tassiopoulos, Deborah Kacanek, Lynne M. Mofenson, Tracie L Miller, Linda A. Dimeglio, D. Heather Watts

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the association of tenofovir disoproxil fumarate (TDF) use during pregnancy with early growth parameters in HIV-exposed, uninfected (HEU) infants. Design: US-based prospective cohort study of HEU children to examine potential adverse effects of prenatal TDF exposure. Methods: We evaluated the association of maternal TDF use during pregnancy with small for gestational age (SGA); low birth weight (LBW, <2.5 kg); weight-for-age z-scores (WAZ), length-for-age z-scores (LAZ), and head circumference-for-age (HCAZ) z-scores at newborn visit; and LAZ, HCAZ, and WAZ at age 1 year. Logistic regression models for LBW and SGA were fit, adjusting for maternal and sociodemographic factors. Adjusted linear regression models were used to evaluate LAZ, WAZ, and HCAZ by TDF exposure. Results: Of 2029 enrolled children with maternal antiretroviral information, TDF was used by 449 (21%) HIV-infected mothers, increasing from 14% in 2003 to 43% in 2010. There was no difference between those exposed to combination regimens with vs. without TDF for SGA, LBW, and newborn LAZ and HCAZ. However, at age 1 year, infants exposed to combination regimens with TDF had significantly lower adjusted mean LAZ and HCAZ than those without TDF (LAZ:-0.17 vs.-0.03, P = 0.04; HCAZ: 0.17 vs. 0.42, P = 0.02). Conclusion: TDF use during pregnancy was not associated with increased risk for LBW or SGA. The slightly lower mean LAZ and HCAZ observed at age 1 year in TDF-exposed infants are of uncertain significance but underscore the need for additional studies of growth outcomes after TDF use during pregnancy.

Original languageEnglish
Pages (from-to)1151-1159
Number of pages9
JournalAIDS
Volume26
Issue number9
DOIs
StatePublished - Jun 1 2012

Fingerprint

Tenofovir
HIV
Safety
Pregnancy
Growth
Gestational Age
Mothers
Weights and Measures
Linear Models
Logistic Models
Newborn Infant

Keywords

  • antiretroviral drugs
  • infant growth
  • perinatal HIV exposure
  • pregnancy
  • tenofovir disoproxil fumarate

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Siberry, G. K., Williams, P. L., Mendez, H., Seage, G. R., Jacobson, D. L., Hazra, R., ... Watts, D. H. (2012). Safety of tenofovir use during pregnancy: Early growth outcomes in HIV-exposed uninfected infants. AIDS, 26(9), 1151-1159. https://doi.org/10.1097/QAD.0b013e328352d135

Safety of tenofovir use during pregnancy : Early growth outcomes in HIV-exposed uninfected infants. / Siberry, George K.; Williams, Paige L.; Mendez, Hermann; Seage, George R.; Jacobson, Denise L.; Hazra, Rohan; Rich, Kenneth C.; Griner, Raymond; Tassiopoulos, Katherine; Kacanek, Deborah; Mofenson, Lynne M.; Miller, Tracie L; Dimeglio, Linda A.; Watts, D. Heather.

In: AIDS, Vol. 26, No. 9, 01.06.2012, p. 1151-1159.

Research output: Contribution to journalArticle

Siberry, GK, Williams, PL, Mendez, H, Seage, GR, Jacobson, DL, Hazra, R, Rich, KC, Griner, R, Tassiopoulos, K, Kacanek, D, Mofenson, LM, Miller, TL, Dimeglio, LA & Watts, DH 2012, 'Safety of tenofovir use during pregnancy: Early growth outcomes in HIV-exposed uninfected infants', AIDS, vol. 26, no. 9, pp. 1151-1159. https://doi.org/10.1097/QAD.0b013e328352d135
Siberry GK, Williams PL, Mendez H, Seage GR, Jacobson DL, Hazra R et al. Safety of tenofovir use during pregnancy: Early growth outcomes in HIV-exposed uninfected infants. AIDS. 2012 Jun 1;26(9):1151-1159. https://doi.org/10.1097/QAD.0b013e328352d135
Siberry, George K. ; Williams, Paige L. ; Mendez, Hermann ; Seage, George R. ; Jacobson, Denise L. ; Hazra, Rohan ; Rich, Kenneth C. ; Griner, Raymond ; Tassiopoulos, Katherine ; Kacanek, Deborah ; Mofenson, Lynne M. ; Miller, Tracie L ; Dimeglio, Linda A. ; Watts, D. Heather. / Safety of tenofovir use during pregnancy : Early growth outcomes in HIV-exposed uninfected infants. In: AIDS. 2012 ; Vol. 26, No. 9. pp. 1151-1159.
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