Abstract
Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (L-glutamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that L-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of 'active resuscitation' of energy-depleted hearts.
| Original language | English |
|---|---|
| Pages (from-to) | 402-410 |
| Number of pages | 9 |
| Journal | Journal of Thoracic and Cardiovascular Surgery |
| Volume | 88 |
| Issue number | 3 |
| State | Published - Nov 1 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts. / Rosenkranz, Eliot; Okamoto, F.; Buckberg, G. D.; Vinten-Johansen, J.; Robertson, J. M.; Bugyi, H.
In: Journal of Thoracic and Cardiovascular Surgery, Vol. 88, No. 3, 01.11.1984, p. 402-410.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts
AU - Rosenkranz, Eliot
AU - Okamoto, F.
AU - Buckberg, G. D.
AU - Vinten-Johansen, J.
AU - Robertson, J. M.
AU - Bugyi, H.
PY - 1984/11/1
Y1 - 1984/11/1
N2 - Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (L-glutamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that L-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of 'active resuscitation' of energy-depleted hearts.
AB - Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (L-glutamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that L-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of 'active resuscitation' of energy-depleted hearts.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021271580&partnerID=8YFLogxK
M3 - Article
C2 - 6147442
AN - SCOPUS:0021271580
VL - 88
SP - 402
EP - 410
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
SN - 0022-5223
IS - 3
ER -