Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts

Eliot Rosenkranz, F. Okamoto, G. D. Buckberg, J. Vinten-Johansen, J. M. Robertson, H. Bugyi

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (L-glutamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that L-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of 'active resuscitation' of energy-depleted hearts.

Original languageEnglish
Pages (from-to)402-410
Number of pages9
JournalJournal of Thoracic and Cardiovascular Surgery
Volume88
Issue number3
StatePublished - Nov 1 1984
Externally publishedYes

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Induced Heart Arrest
Constriction
Glutamic Acid
Cardioplegic Solutions
Safety
Anaerobiosis
Resuscitation
Oxygen Consumption
Amino Acids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts. / Rosenkranz, Eliot; Okamoto, F.; Buckberg, G. D.; Vinten-Johansen, J.; Robertson, J. M.; Bugyi, H.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 88, No. 3, 01.11.1984, p. 402-410.

Research output: Contribution to journalArticle

Rosenkranz, Eliot ; Okamoto, F. ; Buckberg, G. D. ; Vinten-Johansen, J. ; Robertson, J. M. ; Bugyi, H. / Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts. In: Journal of Thoracic and Cardiovascular Surgery. 1984 ; Vol. 88, No. 3. pp. 402-410.
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