Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts

E. R. Rosenkranz, F. Okamoto, G. D. Buckberg, J. Vinten-Johansen, J. M. Robertson, H. Bugyi

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted hearts during aortic clamping. This study extends our previous observations on the benefits of amino acid (L-glutamate) enrichment of blood cardioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts. The results demonstrate that L-glutamate enrichment of blood cardioplegic solutions significantly improves metabolic recovery (greater oxygen consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of 'active resuscitation' of energy-depleted hearts.

Original languageEnglish (US)
Pages (from-to)402-410
Number of pages9
JournalJournal of Thoracic and Cardiovascular Surgery
Volume88
Issue number3
StatePublished - Nov 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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