Safety and outcomes of simultaneous vasospasm and endovascular aneurysm treatment (SVAT) in subarachnoid hemorrhage

Doniel Drazin, Vernard S. Fennell, Edward Gifford, Carlito Lagman, Kunakorn Atchaneeyasakul, Randall C. Edgell, Mahmoud Rayes, Andrew Xavier, Muhammad S. Hussain, Rishi Gupta, Junaid S. Kalia, Osama O. Zaidat, Italo Linfante, Raul G. Nogueira, Thanh Nguyen, Jamary Oliveira-Filho, Alexandre D.M. Barros, Alan Boulos, Michael J. Alexander, Dileep R Yavagal

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Simultaneous vasospasm and endovascular aneurysm treatment (SVAT) has been shown to be effective with good clinical outcomes in small series, but these studies have not examined predictive factors for clinical outcome after treatment. Objective To identify the safety and efficacy of SVAT in a large multicenter patient cohort and evaluate prognostic markers of clinical outcome following SVAT. Methods This study retrospectively enrolled 50 consecutive patients undergoing SVAT at 11 different centers. We analyzed Hunt and Hess and Fisher grades, aneurysm location, angiographic vasospasm grade, Glasgow Outcome Scale (GOS) at discharge, and 90-day modified Rankin Scale (mRS) scores. Results A total of 50 patients undergoing SVAT between the years 2003 and 2009 were identified. Patients presented, on average, 6.48±4.45€ days after subarachnoid hemorrhage. Hunt and Hess and Fisher grades were 1 (n=7), 2 (n=12), 3 (n=14), 4 (n=15), 5 (n=2), and 3 and 4 (n=33), respectively. Aneurysm location was distributed as follows: anterior (n=32), posterior (n=16), anterior and posterior (n=2). Patients with good clinical condition (Hunt and Hess score 1-3) had significantly higher odds of surviving (OR=17.5, 95% CI 1.9 to 161.5), favorable GOS (OR=4.2, 95% CI 1.2 to 14.8), and favorable 90-day mRS (OR=4.2, 95% CI 1.2 to 14.8). Conclusions SVAT is safe, with the majority of patients achieving good clinical outcome. Patients with lower Hunt and Hess grades have higher odds of surviving and favorable clinical prognosis.

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
JournalJournal of NeuroInterventional Surgery
Volume9
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

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Subarachnoid Hemorrhage
Aneurysm
Safety
Glasgow Outcome Scale
Therapeutics
Biomarkers

Keywords

  • Aneurysm
  • Balloon
  • Embolic
  • Hemorrhage
  • Subarachnoid

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Safety and outcomes of simultaneous vasospasm and endovascular aneurysm treatment (SVAT) in subarachnoid hemorrhage. / Drazin, Doniel; Fennell, Vernard S.; Gifford, Edward; Lagman, Carlito; Atchaneeyasakul, Kunakorn; Edgell, Randall C.; Rayes, Mahmoud; Xavier, Andrew; Hussain, Muhammad S.; Gupta, Rishi; Kalia, Junaid S.; Zaidat, Osama O.; Linfante, Italo; Nogueira, Raul G.; Nguyen, Thanh; Oliveira-Filho, Jamary; Barros, Alexandre D.M.; Boulos, Alan; Alexander, Michael J.; Yavagal, Dileep R.

In: Journal of NeuroInterventional Surgery, Vol. 9, No. 5, 01.05.2017, p. 482-485.

Research output: Contribution to journalArticle

Drazin, D, Fennell, VS, Gifford, E, Lagman, C, Atchaneeyasakul, K, Edgell, RC, Rayes, M, Xavier, A, Hussain, MS, Gupta, R, Kalia, JS, Zaidat, OO, Linfante, I, Nogueira, RG, Nguyen, T, Oliveira-Filho, J, Barros, ADM, Boulos, A, Alexander, MJ & Yavagal, DR 2017, 'Safety and outcomes of simultaneous vasospasm and endovascular aneurysm treatment (SVAT) in subarachnoid hemorrhage', Journal of NeuroInterventional Surgery, vol. 9, no. 5, pp. 482-485. https://doi.org/10.1136/neurintsurg-2016-012714
Drazin, Doniel ; Fennell, Vernard S. ; Gifford, Edward ; Lagman, Carlito ; Atchaneeyasakul, Kunakorn ; Edgell, Randall C. ; Rayes, Mahmoud ; Xavier, Andrew ; Hussain, Muhammad S. ; Gupta, Rishi ; Kalia, Junaid S. ; Zaidat, Osama O. ; Linfante, Italo ; Nogueira, Raul G. ; Nguyen, Thanh ; Oliveira-Filho, Jamary ; Barros, Alexandre D.M. ; Boulos, Alan ; Alexander, Michael J. ; Yavagal, Dileep R. / Safety and outcomes of simultaneous vasospasm and endovascular aneurysm treatment (SVAT) in subarachnoid hemorrhage. In: Journal of NeuroInterventional Surgery. 2017 ; Vol. 9, No. 5. pp. 482-485.
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abstract = "Background Simultaneous vasospasm and endovascular aneurysm treatment (SVAT) has been shown to be effective with good clinical outcomes in small series, but these studies have not examined predictive factors for clinical outcome after treatment. Objective To identify the safety and efficacy of SVAT in a large multicenter patient cohort and evaluate prognostic markers of clinical outcome following SVAT. Methods This study retrospectively enrolled 50 consecutive patients undergoing SVAT at 11 different centers. We analyzed Hunt and Hess and Fisher grades, aneurysm location, angiographic vasospasm grade, Glasgow Outcome Scale (GOS) at discharge, and 90-day modified Rankin Scale (mRS) scores. Results A total of 50 patients undergoing SVAT between the years 2003 and 2009 were identified. Patients presented, on average, 6.48±4.45€ days after subarachnoid hemorrhage. Hunt and Hess and Fisher grades were 1 (n=7), 2 (n=12), 3 (n=14), 4 (n=15), 5 (n=2), and 3 and 4 (n=33), respectively. Aneurysm location was distributed as follows: anterior (n=32), posterior (n=16), anterior and posterior (n=2). Patients with good clinical condition (Hunt and Hess score 1-3) had significantly higher odds of surviving (OR=17.5, 95{\%} CI 1.9 to 161.5), favorable GOS (OR=4.2, 95{\%} CI 1.2 to 14.8), and favorable 90-day mRS (OR=4.2, 95{\%} CI 1.2 to 14.8). Conclusions SVAT is safe, with the majority of patients achieving good clinical outcome. Patients with lower Hunt and Hess grades have higher odds of surviving and favorable clinical prognosis.",
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T1 - Safety and outcomes of simultaneous vasospasm and endovascular aneurysm treatment (SVAT) in subarachnoid hemorrhage

AU - Drazin, Doniel

AU - Fennell, Vernard S.

AU - Gifford, Edward

AU - Lagman, Carlito

AU - Atchaneeyasakul, Kunakorn

AU - Edgell, Randall C.

AU - Rayes, Mahmoud

AU - Xavier, Andrew

AU - Hussain, Muhammad S.

AU - Gupta, Rishi

AU - Kalia, Junaid S.

AU - Zaidat, Osama O.

AU - Linfante, Italo

AU - Nogueira, Raul G.

AU - Nguyen, Thanh

AU - Oliveira-Filho, Jamary

AU - Barros, Alexandre D.M.

AU - Boulos, Alan

AU - Alexander, Michael J.

AU - Yavagal, Dileep R

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background Simultaneous vasospasm and endovascular aneurysm treatment (SVAT) has been shown to be effective with good clinical outcomes in small series, but these studies have not examined predictive factors for clinical outcome after treatment. Objective To identify the safety and efficacy of SVAT in a large multicenter patient cohort and evaluate prognostic markers of clinical outcome following SVAT. Methods This study retrospectively enrolled 50 consecutive patients undergoing SVAT at 11 different centers. We analyzed Hunt and Hess and Fisher grades, aneurysm location, angiographic vasospasm grade, Glasgow Outcome Scale (GOS) at discharge, and 90-day modified Rankin Scale (mRS) scores. Results A total of 50 patients undergoing SVAT between the years 2003 and 2009 were identified. Patients presented, on average, 6.48±4.45€ days after subarachnoid hemorrhage. Hunt and Hess and Fisher grades were 1 (n=7), 2 (n=12), 3 (n=14), 4 (n=15), 5 (n=2), and 3 and 4 (n=33), respectively. Aneurysm location was distributed as follows: anterior (n=32), posterior (n=16), anterior and posterior (n=2). Patients with good clinical condition (Hunt and Hess score 1-3) had significantly higher odds of surviving (OR=17.5, 95% CI 1.9 to 161.5), favorable GOS (OR=4.2, 95% CI 1.2 to 14.8), and favorable 90-day mRS (OR=4.2, 95% CI 1.2 to 14.8). Conclusions SVAT is safe, with the majority of patients achieving good clinical outcome. Patients with lower Hunt and Hess grades have higher odds of surviving and favorable clinical prognosis.

AB - Background Simultaneous vasospasm and endovascular aneurysm treatment (SVAT) has been shown to be effective with good clinical outcomes in small series, but these studies have not examined predictive factors for clinical outcome after treatment. Objective To identify the safety and efficacy of SVAT in a large multicenter patient cohort and evaluate prognostic markers of clinical outcome following SVAT. Methods This study retrospectively enrolled 50 consecutive patients undergoing SVAT at 11 different centers. We analyzed Hunt and Hess and Fisher grades, aneurysm location, angiographic vasospasm grade, Glasgow Outcome Scale (GOS) at discharge, and 90-day modified Rankin Scale (mRS) scores. Results A total of 50 patients undergoing SVAT between the years 2003 and 2009 were identified. Patients presented, on average, 6.48±4.45€ days after subarachnoid hemorrhage. Hunt and Hess and Fisher grades were 1 (n=7), 2 (n=12), 3 (n=14), 4 (n=15), 5 (n=2), and 3 and 4 (n=33), respectively. Aneurysm location was distributed as follows: anterior (n=32), posterior (n=16), anterior and posterior (n=2). Patients with good clinical condition (Hunt and Hess score 1-3) had significantly higher odds of surviving (OR=17.5, 95% CI 1.9 to 161.5), favorable GOS (OR=4.2, 95% CI 1.2 to 14.8), and favorable 90-day mRS (OR=4.2, 95% CI 1.2 to 14.8). Conclusions SVAT is safe, with the majority of patients achieving good clinical outcome. Patients with lower Hunt and Hess grades have higher odds of surviving and favorable clinical prognosis.

KW - Aneurysm

KW - Balloon

KW - Embolic

KW - Hemorrhage

KW - Subarachnoid

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