Abstract
Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.
| Original language | English |
|---|---|
| Pages (from-to) | 336-340 |
| Number of pages | 5 |
| Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| Volume | 85 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Parasitology
- Medicine(all)
Cite this
Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine : boosting of antibody response in a population with prior natural exposure to malaria. / Sherwood, J. A.; Oster, C. N.; Adoyo-Adoyo, M.; Beier, John C; Gachihi, G. S.; Nyakundi, P. M.; Ballou, W. R.; Brandling-Bennett, A. D.; Schwartz, I. K.; Were, J. B O; Wirtz, R. A.; Schneider, I.; Roberts, C. R.; Young, J. F.; Gross, M.; Chulay, J. D.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 85, No. 3, 01.01.1991, p. 336-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine
T2 - boosting of antibody response in a population with prior natural exposure to malaria
AU - Sherwood, J. A.
AU - Oster, C. N.
AU - Adoyo-Adoyo, M.
AU - Beier, John C
AU - Gachihi, G. S.
AU - Nyakundi, P. M.
AU - Ballou, W. R.
AU - Brandling-Bennett, A. D.
AU - Schwartz, I. K.
AU - Were, J. B O
AU - Wirtz, R. A.
AU - Schneider, I.
AU - Roberts, C. R.
AU - Young, J. F.
AU - Gross, M.
AU - Chulay, J. D.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.
AB - Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.
UR - http://www.scopus.com/inward/record.url?scp=0025892669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025892669&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(91)90281-3
DO - 10.1016/0035-9203(91)90281-3
M3 - Article
C2 - 1949134
AN - SCOPUS:0025892669
VL - 85
SP - 336
EP - 340
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 3
ER -