Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria

J. A. Sherwood, C. N. Oster, M. Adoyo-Adoyo, J. C. Beier, G. S. Gachihi, P. M. Nyakundi, W. R. Ballou, A. D. Brandling-Bennett, I. K. Schwartz, J. B.O. Were, R. A. Wirtz, I. Schneider, C. R. Roberts, J. F. Young, M. Gross, J. D. Chulay

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.

Original languageEnglish (US)
Pages (from-to)336-340
Number of pages5
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume85
Issue number3
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Sherwood, J. A., Oster, C. N., Adoyo-Adoyo, M., Beier, J. C., Gachihi, G. S., Nyakundi, P. M., Ballou, W. R., Brandling-Bennett, A. D., Schwartz, I. K., Were, J. B. O., Wirtz, R. A., Schneider, I., Roberts, C. R., Young, J. F., Gross, M., & Chulay, J. D. (1991). Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85(3), 336-340. https://doi.org/10.1016/0035-9203(91)90281-3