Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria

J. A. Sherwood; C. N. Oster; M. Adoyo-Adoyo; J. C. Beier; G. S. Gachihi; P. M. Nyakundi; W. R. Ballou; A. D. Brandling-Bennett; I. K. Schwartz; J. B.O. Were; R. A. Wirtz; I. Schneider; C. R. Roberts; J. F. Young; M. Gross; J. D. Chulay

doi:10.1016/0035-9203(91)90281-3

Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria

J. A. Sherwood, C. N. Oster, M. Adoyo-Adoyo, J. C. Beier, G. S. Gachihi, P. M. Nyakundi, W. R. Ballou, A. D. Brandling-Bennett, I. K. Schwartz, J. B.O. Were, R. A. Wirtz, I. Schneider, C. R. Roberts, J. F. Young, M. Gross, J. D. Chulay

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.

Original language	English (US)
Pages (from-to)	336-340
Number of pages	5
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	85
Issue number	3
DOIs	https://doi.org/10.1016/0035-9203(91)90281-3
State	Published - Jan 1 1991
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1016/0035-9203(91)90281-3

Fingerprint Dive into the research topics of 'Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria'. Together they form a unique fingerprint.

Cite this

Sherwood, J. A., Oster, C. N., Adoyo-Adoyo, M., Beier, J. C., Gachihi, G. S., Nyakundi, P. M., Ballou, W. R., Brandling-Bennett, A. D., Schwartz, I. K., Were, J. B. O., Wirtz, R. A., Schneider, I., Roberts, C. R., Young, J. F., Gross, M., & Chulay, J. D. (1991). Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85(3), 336-340. https://doi.org/10.1016/0035-9203(91)90281-3

Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine : boosting of antibody response in a population with prior natural exposure to malaria. / Sherwood, J. A.; Oster, C. N.; Adoyo-Adoyo, M.; Beier, J. C.; Gachihi, G. S.; Nyakundi, P. M.; Ballou, W. R.; Brandling-Bennett, A. D.; Schwartz, I. K.; Were, J. B.O.; Wirtz, R. A.; Schneider, I.; Roberts, C. R.; Young, J. F.; Gross, M.; Chulay, J. D.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 85, No. 3, 01.01.1991, p. 336-340.

Research output: Contribution to journal › Article › peer-review

Sherwood, JA, Oster, CN, Adoyo-Adoyo, M, Beier, JC, Gachihi, GS, Nyakundi, PM, Ballou, WR, Brandling-Bennett, AD, Schwartz, IK, Were, JBO, Wirtz, RA, Schneider, I, Roberts, CR, Young, JF, Gross, M & Chulay, JD 1991, 'Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 85, no. 3, pp. 336-340. https://doi.org/10.1016/0035-9203(91)90281-3

Sherwood JA, Oster CN, Adoyo-Adoyo M, Beier JC, Gachihi GS, Nyakundi PM et al. Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1991 Jan 1;85(3):336-340. https://doi.org/10.1016/0035-9203(91)90281-3

Sherwood, J. A. ; Oster, C. N. ; Adoyo-Adoyo, M. ; Beier, J. C. ; Gachihi, G. S. ; Nyakundi, P. M. ; Ballou, W. R. ; Brandling-Bennett, A. D. ; Schwartz, I. K. ; Were, J. B.O. ; Wirtz, R. A. ; Schneider, I. ; Roberts, C. R. ; Young, J. F. ; Gross, M. ; Chulay, J. D. / Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine : boosting of antibody response in a population with prior natural exposure to malaria. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 1991 ; Vol. 85, No. 3. pp. 336-340.

@article{3bc04a9a1aac4bd7822be1db0c5cef82,

title = "Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria",

abstract = "Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.",

author = "Sherwood, {J. A.} and Oster, {C. N.} and M. Adoyo-Adoyo and Beier, {J. C.} and Gachihi, {G. S.} and Nyakundi, {P. M.} and Ballou, {W. R.} and Brandling-Bennett, {A. D.} and Schwartz, {I. K.} and Were, {J. B.O.} and Wirtz, {R. A.} and I. Schneider and Roberts, {C. R.} and Young, {J. F.} and M. Gross and Chulay, {J. D.}",

year = "1991",

month = jan,

day = "1",

doi = "10.1016/0035-9203(91)90281-3",

language = "English (US)",

volume = "85",

pages = "336--340",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine

T2 - boosting of antibody response in a population with prior natural exposure to malaria

AU - Sherwood, J. A.

AU - Oster, C. N.

AU - Adoyo-Adoyo, M.

AU - Beier, J. C.

AU - Gachihi, G. S.

AU - Nyakundi, P. M.

AU - Ballou, W. R.

AU - Brandling-Bennett, A. D.

AU - Schwartz, I. K.

AU - Were, J. B.O.

AU - Wirtz, R. A.

AU - Schneider, I.

AU - Roberts, C. R.

AU - Young, J. F.

AU - Gross, M.

AU - Chulay, J. D.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.

AB - Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0·43 ± 0·40 with vaccine, 0·01 ± 0·23 with placebo, and 0·72 ± 0·19 in responders. Six non-responders had significantly lower pre-immunization levels (0·07 ± 0·05) than responders (0·39 ± 0·25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria.

UR - http://www.scopus.com/inward/record.url?scp=0025892669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025892669&partnerID=8YFLogxK

U2 - 10.1016/0035-9203(91)90281-3

DO - 10.1016/0035-9203(91)90281-3

M3 - Article

C2 - 1949134

AN - SCOPUS:0025892669

VL - 85

SP - 336

EP - 340

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 3

ER -

Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this