Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor

Lily Park, Thomas F. DeLaney, Norbert J. Liebsch, Francis J. Hornicek, Saveli Goldberg, Henry Mankin, Andrew Rosenberg, Daniel I. Rosenthal, Herman D. Suit

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Purpose: To assess the efficacy of definitive treatment of sacral chordoma by high-dose proton/photon-beam radiation therapy alone or combined with surgery. Methods and Materials: The records of 16 primary and 11 recurrent sacral chordoma patients treated from November 1982 to November 2002 by proton/photon radiation therapy alone (6 patients) or combined with surgery (21 patients) have been analyzed for local control, survival, and treatment-related morbidity. The outcome analysis is based on follow-up information as of 2005. Results: Outcome results show a large difference in local failure rate between patients treated for primary and recurrent chordomas. Local control results by surgery and radiation were 12/14 vs. 1/7 for primary and recurrent lesions. For margin-positive patients, local control results were 10 of 11 and 0 of 5 in the primary and recurrent groups, respectively; the mean follow-up on these locally controlled patients was 8.8 years (4 at 10.3, 12.8, 17, and 21 years). Radiation alone was used in 6 patients, 4 of whom received ≥73.0 Gy (E); local control was observed in 3 of these 4 patients for 2.9, 4.9, and 7.6 years. Conclusion: These data indicate a high local control rate for surgical and radiation treatment of primary (12 of 14) as distinct from recurrent (1 of 7) sacral chordomas. Three of 4 chordomas treated by ≥73.0 Gy (E) of radiation alone had local control; 1 is at 91 months. This indicates that high-dose proton/photon therapy offers an effective treatment option.

Original languageEnglish
Pages (from-to)1514-1521
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume65
Issue number5
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

Chordoma
photon beams
proton beams
Photons
surgery
Protons
radiation therapy
Radiotherapy
tumors
dosage
Neoplasms
radiation
Radiation
Proton Therapy
Radiation Dosage
protons
photons
lesions
margins
therapy

Keywords

  • Chordoma
  • Proton therapy
  • Radiation therapy
  • Sacrum

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Sacral chordomas : Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. / Park, Lily; DeLaney, Thomas F.; Liebsch, Norbert J.; Hornicek, Francis J.; Goldberg, Saveli; Mankin, Henry; Rosenberg, Andrew; Rosenthal, Daniel I.; Suit, Herman D.

In: International Journal of Radiation Oncology Biology Physics, Vol. 65, No. 5, 01.08.2006, p. 1514-1521.

Research output: Contribution to journalArticle

Park, Lily ; DeLaney, Thomas F. ; Liebsch, Norbert J. ; Hornicek, Francis J. ; Goldberg, Saveli ; Mankin, Henry ; Rosenberg, Andrew ; Rosenthal, Daniel I. ; Suit, Herman D. / Sacral chordomas : Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. In: International Journal of Radiation Oncology Biology Physics. 2006 ; Vol. 65, No. 5. pp. 1514-1521.
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