RU486 in depression

K. Ranga Rama Krishnan, Deborah Reed, William H. Wilson, William B. Saunders, James C. Ritchie, Charles B. Nemeroff, Bernard J. Carroll

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Krishnan K. Ranga R., Deborah Reed, William H. Wilson, William Saunders, James C. Ritchie, Charles B. Nemeroff and Bernard J. Carroll: RU486 in depression. Prog. Neuro-Psychopharmacol. & Biol Psychiat. 1992, 16(6): 913-920. 1. 1. RU486 is a synthetic glucocorticoid antagonist.The authors used RU486 to examine the hypothesis that the elevated plasma cortisol and ACTH in patients is due to suprahypophyseal stimulation of the anterior pituitary. 2. 2. Seven patients and matched controls were studied before and after the administration of RU486. 3. 3. RU486 produced an increase in HPA activity in depressed patients. Thus providing support for the hypothesis that there is increased suprahypophyseal stimulation of the anterior pituitary.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume16
Issue number6
DOIs
StatePublished - Nov 1992
Externally publishedYes

Keywords

  • depression
  • plasma ACTH
  • plasma cortisol
  • RU486

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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  • Cite this

    Krishnan, K. R. R., Reed, D., Wilson, W. H., Saunders, W. B., Ritchie, J. C., Nemeroff, C. B., & Carroll, B. J. (1992). RU486 in depression. Progress in Neuropsychopharmacology and Biological Psychiatry, 16(6), 913-920. https://doi.org/10.1016/0278-5846(92)90109-R