RS3PE: Clinical and Research Development

Hongbin Li; Roy D Altman; Qingping Yao

doi:10.1007/s11926-015-0525-0

RS3PE: Clinical and Research Development

Hongbin Li, Roy D Altman, Qingping Yao

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Remitting seronegative symmetrical synovitis with pitting edema or RS3PE is a rare elderly-onset rheumatic syndrome. Although there are overlapping clinical manifestations between RS3PE, elderly-onset rheumatoid arthritis, and polymyalgia rheumatica, RS3PE has distinct characteristics. RS3PE can be associated with neoplasia and various rheumatic conditions, suggesting that it may be heterogeneous, and is considered as a paraneoplastic rheumatic disease. The pathogenesis of RS3PE may involve vascular endothelial growth factor and infection in RS3PE based upon limited data. Patients with RS3PE without concomitant malignancy respond well to small doses of glucocorticoids and carry good prognosis.

Original language	English (US)
Article number	49
Journal	Current Rheumatology Reports
Volume	17
Issue number	8
DOIs	https://doi.org/10.1007/s11926-015-0525-0
State	Published - Aug 27 2015
Externally published	Yes

Keywords

Infection
Neoplasm
Polymyalgia rheumatica
Rheumatoid arthritis
RS3PE
Vascular endothelial growth factor

ASJC Scopus subject areas

Rheumatology

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AU - Yao, Qingping

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AB - Remitting seronegative symmetrical synovitis with pitting edema or RS3PE is a rare elderly-onset rheumatic syndrome. Although there are overlapping clinical manifestations between RS3PE, elderly-onset rheumatoid arthritis, and polymyalgia rheumatica, RS3PE has distinct characteristics. RS3PE can be associated with neoplasia and various rheumatic conditions, suggesting that it may be heterogeneous, and is considered as a paraneoplastic rheumatic disease. The pathogenesis of RS3PE may involve vascular endothelial growth factor and infection in RS3PE based upon limited data. Patients with RS3PE without concomitant malignancy respond well to small doses of glucocorticoids and carry good prognosis.

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RS3PE: Clinical and Research Development

Abstract

Keywords

ASJC Scopus subject areas

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