RS3PE: Clinical and Research Development

Hongbin Li, Roy D Altman, Qingping Yao

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Remitting seronegative symmetrical synovitis with pitting edema or RS3PE is a rare elderly-onset rheumatic syndrome. Although there are overlapping clinical manifestations between RS3PE, elderly-onset rheumatoid arthritis, and polymyalgia rheumatica, RS3PE has distinct characteristics. RS3PE can be associated with neoplasia and various rheumatic conditions, suggesting that it may be heterogeneous, and is considered as a paraneoplastic rheumatic disease. The pathogenesis of RS3PE may involve vascular endothelial growth factor and infection in RS3PE based upon limited data. Patients with RS3PE without concomitant malignancy respond well to small doses of glucocorticoids and carry good prognosis.

Original languageEnglish (US)
Article number49
JournalCurrent Rheumatology Reports
Issue number8
StatePublished - Aug 27 2015
Externally publishedYes


  • Infection
  • Neoplasm
  • Polymyalgia rheumatica
  • Rheumatoid arthritis
  • RS3PE
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Rheumatology


Dive into the research topics of 'RS3PE: Clinical and Research Development'. Together they form a unique fingerprint.

Cite this