Routine patch testing with frullanolide mix: An European Environmental and Contact Dermatitis Research Group multicentre study

G. Ducombs, J. P. Lepoittevin, V. Berl, K. E. Andersen, F. M. Brandão, D. P. Bruynzeel, M. Bruze, J. G. Camarasa, P. J. Frosch, A. Goossens, J. M. Lachapelle, A. Lahti, C. J. Le Coz, H. I. Maibach, T. Menné, S. Seidenari, S. Shaw, A. Tosti, J. D. Wilkinson

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/ or in particular occupations.

Original languageEnglish (US)
Pages (from-to)158-161
Number of pages4
JournalContact dermatitis
Volume48
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Keywords

  • Allergic contact dermatitis
  • Asteraceae (Compositae)
  • Frullania
  • Frullanolide
  • Lauraceae
  • Plants
  • Sesquiterpene lactones

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology

Cite this

Ducombs, G., Lepoittevin, J. P., Berl, V., Andersen, K. E., Brandão, F. M., Bruynzeel, D. P., Bruze, M., Camarasa, J. G., Frosch, P. J., Goossens, A., Lachapelle, J. M., Lahti, A., Le Coz, C. J., Maibach, H. I., Menné, T., Seidenari, S., Shaw, S., Tosti, A., & Wilkinson, J. D. (2003). Routine patch testing with frullanolide mix: An European Environmental and Contact Dermatitis Research Group multicentre study. Contact dermatitis, 48(3), 158-161. https://doi.org/10.1034/j.1600-0536.2003.00077.x