Round-Window-Mikrokatheter-assistierte mikrodosierung von gentamycin: Alternative in der behandlung des tinnitus bei patienten mit morbus Meniere

Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.