Round-Window-Mikrokatheter-assistierte mikrodosierung von gentamycin: Alternative in der behandlung des tinnitus bei patienten mit morbus Meniere

Translated title of the contribution: Round-Window-Microcatheter administered microdose of gentamycin: An alternative in treatment of tinnitus associated with Meniere's disease

S. Marks, I. K. Arenberg, Michael E Hoffer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.

Original languageGerman
Pages (from-to)327-331
Number of pages5
JournalLaryngo- Rhino- Otologie
Volume79
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

Fingerprint

Meniere Disease
Tinnitus
Gentamicins
Vertigo
Evoked Response Audiometry
Therapeutics
Pressure
Electrodes
Membranes

Keywords

  • Gentamycin therapy
  • Morbus Meniere
  • Round-Window-Microcatheter
  • Tinnitus

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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title = "Round-Window-Mikrokatheter-assistierte mikrodosierung von gentamycin: Alternative in der behandlung des tinnitus bei patienten mit morbus Meniere",
abstract = "Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83{\%}) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94{\%}). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.",
keywords = "Gentamycin therapy, Morbus Meniere, Round-Window-Microcatheter, Tinnitus",
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AU - Arenberg, I. K.

AU - Hoffer, Michael E

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N2 - Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.

AB - Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.

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KW - Round-Window-Microcatheter

KW - Tinnitus

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