Abstract
Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.
| Original language | German |
|---|---|
| Pages (from-to) | 327-331 |
| Number of pages | 5 |
| Journal | Laryngo- Rhino- Otologie |
| Volume | 79 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2000 |
| Externally published | Yes |
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Keywords
- Gentamycin therapy
- Morbus Meniere
- Round-Window-Microcatheter
- Tinnitus
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Round-Window-Mikrokatheter-assistierte mikrodosierung von gentamycin : Alternative in der behandlung des tinnitus bei patienten mit morbus Meniere. / Marks, S.; Arenberg, I. K.; Hoffer, Michael E.
In: Laryngo- Rhino- Otologie, Vol. 79, No. 6, 06.2000, p. 327-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Round-Window-Mikrokatheter-assistierte mikrodosierung von gentamycin
T2 - Alternative in der behandlung des tinnitus bei patienten mit morbus Meniere
AU - Marks, S.
AU - Arenberg, I. K.
AU - Hoffer, Michael E
PY - 2000/6
Y1 - 2000/6
N2 - Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.
AB - Background: In this study, we review the results of Meniere's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system. Patients and Methods: 11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 μl/h continuously applicated by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analyzed with a follow-up ranging from 6 to 12 months. Results: In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Conclusions: These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Meniere's disease.
KW - Gentamycin therapy
KW - Morbus Meniere
KW - Round-Window-Microcatheter
KW - Tinnitus
UR - http://www.scopus.com/inward/record.url?scp=0033624171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033624171&partnerID=8YFLogxK
U2 - 10.1055/s-2000-9182
DO - 10.1055/s-2000-9182
M3 - Article
C2 - 10923311
AN - SCOPUS:0033624171
VL - 79
SP - 327
EP - 331
JO - Laryngo- Rhino- Otologie
JF - Laryngo- Rhino- Otologie
SN - 0935-8943
IS - 6
ER -