Abstract
Hepatocellular carcinoma (HCC) has traditionally been an attractive system for cancer research because many animal HCC models are available. It is well known that liver tumors in animals can be induced by many different protocols, such as chronic hepatitis viral infections, carcinogens, toxins, steroid hormones, and dietary intervention. Although these different inducers have different cellular targets and modes of cytotoxic effects, their common denominator is the formation of reactive oxygen species (ROS). In this review, we present compelling evidence to support the hypothesis that ROS play important roles in hepatocarcinogenesis and the associated upregulation of drug resistance gene expression.
| Original language | English |
|---|---|
| Pages (from-to) | 701-709 |
| Number of pages | 9 |
| Journal | Molecular Carcinogenesis |
| Volume | 45 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2006 |
Fingerprint
Keywords
- Animal models
- Gene regulation
- Multidrug resistance
- Signal pathway
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
Cite this
Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers. / Kuo, M. Tien; Savaraj, Niramol.
In: Molecular Carcinogenesis, Vol. 45, No. 9, 01.09.2006, p. 701-709.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers
AU - Kuo, M. Tien
AU - Savaraj, Niramol
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Hepatocellular carcinoma (HCC) has traditionally been an attractive system for cancer research because many animal HCC models are available. It is well known that liver tumors in animals can be induced by many different protocols, such as chronic hepatitis viral infections, carcinogens, toxins, steroid hormones, and dietary intervention. Although these different inducers have different cellular targets and modes of cytotoxic effects, their common denominator is the formation of reactive oxygen species (ROS). In this review, we present compelling evidence to support the hypothesis that ROS play important roles in hepatocarcinogenesis and the associated upregulation of drug resistance gene expression.
AB - Hepatocellular carcinoma (HCC) has traditionally been an attractive system for cancer research because many animal HCC models are available. It is well known that liver tumors in animals can be induced by many different protocols, such as chronic hepatitis viral infections, carcinogens, toxins, steroid hormones, and dietary intervention. Although these different inducers have different cellular targets and modes of cytotoxic effects, their common denominator is the formation of reactive oxygen species (ROS). In this review, we present compelling evidence to support the hypothesis that ROS play important roles in hepatocarcinogenesis and the associated upregulation of drug resistance gene expression.
KW - Animal models
KW - Gene regulation
KW - Multidrug resistance
KW - Signal pathway
UR - http://www.scopus.com/inward/record.url?scp=33748807185&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748807185&partnerID=8YFLogxK
U2 - 10.1002/mc.20240
DO - 10.1002/mc.20240
M3 - Article
C2 - 16652372
AN - SCOPUS:33748807185
VL - 45
SP - 701
EP - 709
JO - Molecular Carcinogenesis
JF - Molecular Carcinogenesis
SN - 0899-1987
IS - 9
ER -