Roles of IL-4 and IFN-γ in Stabilizing the T Helper Cell Type 1 and 2 Phenotype

Tetsuo Nakamura, Richard K Lee, Sang Y. Nam, Eckhard R. Podack, Kim Bottomly, Richard A. Flavell

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

It has previously been reported that Th1 CD4 T cell populations can be converted to IL-4 producers, whereas Th2 populations are refractory to IL-12-mediated IFN-γ production. We have recently shown that CD30 is a marker for the IL-4 response and have therefore used CD30 here to study Th1 and Th2 commitment. We show that Th2 cell populations normally show a stable phenotype and fail to respond to IL-12 because of endogenous IL-4 production. IFN-γ abrogates this antagonistic effect of IL-4 and permits the conversion of Th2 populations to IFN-γ producers by IL-12. In the complete absence of IL-4, however, IFN-γ is not required for this transformation, and Th1 cells generated by IL-12 become committed to the Th1 pathway and lose the ability to respond to IL-4. Thus, the balance between local IL-4 and IFN-γ in an immune response is a key factor in determining the outcome of the CD4 effector T cell response.

Original languageEnglish
Pages (from-to)2648-2653
Number of pages6
JournalJournal of Immunology
Volume158
Issue number6
StatePublished - Mar 15 1997

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Th2 Cells
Th1 Cells
Interleukin-4
Phenotype
Interleukin-12
Population
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Nakamura, T., Lee, R. K., Nam, S. Y., Podack, E. R., Bottomly, K., & Flavell, R. A. (1997). Roles of IL-4 and IFN-γ in Stabilizing the T Helper Cell Type 1 and 2 Phenotype. Journal of Immunology, 158(6), 2648-2653.

Roles of IL-4 and IFN-γ in Stabilizing the T Helper Cell Type 1 and 2 Phenotype. / Nakamura, Tetsuo; Lee, Richard K; Nam, Sang Y.; Podack, Eckhard R.; Bottomly, Kim; Flavell, Richard A.

In: Journal of Immunology, Vol. 158, No. 6, 15.03.1997, p. 2648-2653.

Research output: Contribution to journalArticle

Nakamura, T, Lee, RK, Nam, SY, Podack, ER, Bottomly, K & Flavell, RA 1997, 'Roles of IL-4 and IFN-γ in Stabilizing the T Helper Cell Type 1 and 2 Phenotype', Journal of Immunology, vol. 158, no. 6, pp. 2648-2653.
Nakamura T, Lee RK, Nam SY, Podack ER, Bottomly K, Flavell RA. Roles of IL-4 and IFN-γ in Stabilizing the T Helper Cell Type 1 and 2 Phenotype. Journal of Immunology. 1997 Mar 15;158(6):2648-2653.
Nakamura, Tetsuo ; Lee, Richard K ; Nam, Sang Y. ; Podack, Eckhard R. ; Bottomly, Kim ; Flavell, Richard A. / Roles of IL-4 and IFN-γ in Stabilizing the T Helper Cell Type 1 and 2 Phenotype. In: Journal of Immunology. 1997 ; Vol. 158, No. 6. pp. 2648-2653.
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