Roles for VEGF in the adult

Arindel S.R. Maharaj, Patricia A. D'Amore

Research output: Contribution to journalReview article

125 Scopus citations

Abstract

The role of VEGF during development and in pathology is well known, but its function in normal adult tissues is poorly understood. Adverse effects associated with the use of anti-angiogenic therapies targeting VEGF in human pathologies have begun to reveal potential functions of VEGF in quiescent vasculature. Further clues from expression studies of VEGF and its receptors in the adult, from the disease preeclampsia, and from experimental neutralization studies, have suggested that VEGF is involved in endothelial cell survival and fenestration, as well as in the signaling and maintenance of non-endothelial cells. The various biochemical properties of VEGF, and its interaction with other growth factors, may be an important point in determining whether VEGF functions as a maintenance factor versus an angiogenic factor. A thorough understanding of the function of VEGF in the adult may lead to more efficacious pro- and anti-angiogenic therapies.

Original languageEnglish (US)
Pages (from-to)100-113
Number of pages14
JournalMicrovascular Research
Volume74
Issue number2-3
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

Keywords

  • Angiogenesis
  • Anti-angiogenic therapy
  • Avastin
  • Bevacizumab
  • Endothelial cells
  • Fenestrations
  • Preeclampsia
  • VEGF

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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