Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation: A 10-year study

Francesco Cacciatore, Gianluca Testa, Assunta Langellotto, Gianluigi Galizia, David Della-Morte, Gaetano Gargiulo, Agnese Bevilacqua, Maria Teresa Del Genio, Vincenzo Canonico, Franco Rengo, Pasquale Abete

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Background: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. Methods: A total of 358 cognitively impaired elderly subjects (MMSE <24) with and without AF were stratified in low/high (<50/>90) and moderate (>50/<90 bpm) VRr. A 10-year follow-up was performed. Results: Cognitively impaired subjects with dementia at the end of the follow-up were 135 (37.7%): 33 in the presence (75.0%) and 102 (32.5%) in the absence of AF (p < 0.001). Multivariate analysis shows that AF is a strong predictor of dementia (hazard ratio, HR = 4.10; 95% confidence interval, CI = 1.80-9.30, p < 0.001). More importantly, low/high VRr (<50/>90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. Conclusions: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume34
Issue number3-4
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Keywords

  • Atrial fibrillation
  • Cardiac output
  • Cognitive impairment
  • Incidence dementia
  • Rate ventricular response

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience

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  • Cite this

    Cacciatore, F., Testa, G., Langellotto, A., Galizia, G., Della-Morte, D., Gargiulo, G., Bevilacqua, A., Del Genio, M. T., Canonico, V., Rengo, F., & Abete, P. (2012). Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation: A 10-year study. Dementia and Geriatric Cognitive Disorders, 34(3-4), 143-148. https://doi.org/10.1159/000342195