Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohn's disease patients

Inés D. Pousa, José Maté, Xamila Salcedo-Mora, Maria T. Abreu, Ricardo Moreno-Otero, Javier P. Gisbert

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Background: The purposes of this study were to determine soluble angiogenic factors in Crohn's disease (CD) patients and to compare these factors according to the pathological behavior of the disease in order to establish a possible relationship with its evolution in patients with CD. Methods: Blood samples were collected from 70 patients with CD, grouped according to their phenotypic behavior, and from 30 healthy controls. Vascular endothelial growth factor (VEGF), placental growth factor (PlGF), angiopoietin 1 (Ang1), angiopoietin 2 (Ang2), and their cognate receptors [VEGFR1, VEGFR2, and angiopoietin receptor tyrosine kinase (Tie2)] were assayed by ELISA. Results: Circulating levels of VEGF, PlGF, VEGFR1, Ang2, and Tie2 were significantly higher in CD patients than in healthy controls (489 ± 271 versus 335 ± 118 pg/mL, P < 0.001; 31 ± 9 versus 23 ± 9 pg/mL, P < 0.001; 1.7 ± 0.4 versus 1.0 ± 0.3 ng/mL, P < 0.001; 4.8 ± 2.0 versus 3.9 ± 2.0 ng/mL, P < 0.05; and 36 ± 5 versus 22 ± 7 ng/mL, P < 0.001, respectively). Conversely, CD patients showed significantly lower serum levels of Ang1 than healthy controls (40 ± 12 versus 67 ± 22 ng/mL; P < 0.001). No differences between the groups were found in VEGFR2 serum level. The circulating levels of the angiogenic factors did not differ significantly when the CD patients were classified according to pathological phenotype. Conclusions: In comparison with healthy controls, CD patients were found to have an active angiogenic profile, as detected by significant alterations in levels of angiogenesis soluble markers. These patients did not differ in serum levels of angiogenic factors according to phenotypic disease behavior.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalInflammatory bowel diseases
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • Angiogenesis
  • Angiogenic factors
  • Crohn's disease
  • Microvascular development
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Role of vascular endothelial growth factor and angiopoietin systems in serum of Crohn's disease patients'. Together they form a unique fingerprint.

Cite this