Role of Toll-like receptors in gastrointestinal malignancies

M. Fukata, Maria T Abreu

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Mounting evidence supports the tenet that innate immune responses to luminal microbes participate in the development of gastrointestinal malignancies. The gastrointestinal tract is relatively unique in that it has evolved in the presence of diverse enteric microflora. Intestinal flora is required to develop a normal adaptive immune response in the periphery. With the characterization of the innate immune system, we have begun to understand the adaptations the intestine has made to the microbiota. The interaction between the microbiota and the intestinal mucosa through Toll-like receptors (TLRs) is required to maintain intestinal homeostasis. In particular, intestinal epithelial cells and lamina propria mononuclear cells such as antigen-presenting cells and T cells must respond to breaches in the mucosal barrier by activating TLR-dependent pathways that result in increased epithelial proliferation, wound healing and recruitment of acute inflammatory cells. In the setting of chronic inflammation such as Helicobacter pylori (H. pylori) infection in the stomach or idiopathic inflammatory bowel disease, the process of repair may eventually result in carcinogenesis. The following review highlights human and animal data that support a role for innate immune responses and TLRs specifically in promoting gastrointestinal malignancies. Candidate pathways linking TLRs to gastrointestinal malignancies include activation of nuclear factor-κB and cyclooxygenase-2. Studying the link between innate immune signaling and gastrointestinal malignancies offers the possibility to identify novel ways to both prevent and treat gastrointestinal cancer.

Original languageEnglish
Pages (from-to)234-243
Number of pages10
JournalOncogene
Volume27
Issue number2
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Toll-Like Receptors
Microbiota
Innate Immunity
Neoplasms
Gastrointestinal Neoplasms
Helicobacter Infections
Adaptive Immunity
Antigen-Presenting Cells
Cyclooxygenase 2
Intestinal Mucosa
Inflammatory Bowel Diseases
Helicobacter pylori
Wound Healing
Intestines
Gastrointestinal Tract
Immune System
Stomach
Carcinogenesis
Mucous Membrane
Homeostasis

Keywords

  • Cancer
  • Colon
  • Inflammation
  • Intestine
  • Stomach
  • Toll-like receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Role of Toll-like receptors in gastrointestinal malignancies. / Fukata, M.; Abreu, Maria T.

In: Oncogene, Vol. 27, No. 2, 01.01.2008, p. 234-243.

Research output: Contribution to journalArticle

Fukata, M. ; Abreu, Maria T. / Role of Toll-like receptors in gastrointestinal malignancies. In: Oncogene. 2008 ; Vol. 27, No. 2. pp. 234-243.
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