Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis

Claudia N. Emami, Mikael Petrosyan, Stefano Giuliani, Monica Williams, Catherine Hunter, Nemani V. Prasadarao, Henri Ford

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Background: Necrotizing enterocolitis (NEC) is a devastating disease that affects primarily the intestine of premature infants. Despite recent advances in neonatology, NEC remains a major cause of morbidity and mortality in neonates. Neonatal mucosal defenses and adherence of bacterial pathogens may play an important role in the pathogenesis of NEC. Methods: Review and synthesis of pertinent literature. Results: Putative factors that have been implicated in the pathogenesis of NEC include abnormal patterns of gut colonization by bacteria, immaturity of the host immune system and mucosal defense mechanisms, intestinal ischemia, formula feeding, and loss of intestinal epithelial barrier integrity. Conclusion: Host defenses and intestinal microbial ecology are believed to play important roles in the pathogenesis of NEC. Commensal bacteria and probiotic therapy may be of therapeutic utility in the maintenance of the gut epithelial barrier.

Original languageEnglish (US)
Pages (from-to)407-417
Number of pages11
JournalSurgical Infections
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

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Necrotizing Enterocolitis
Neonatology
Bacteria
Probiotics
Ecology
Premature Infants
Intestines
Immune System
Ischemia
Maintenance
Gastrointestinal Microbiome
Newborn Infant
Morbidity
Mortality
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis. / Emami, Claudia N.; Petrosyan, Mikael; Giuliani, Stefano; Williams, Monica; Hunter, Catherine; Prasadarao, Nemani V.; Ford, Henri.

In: Surgical Infections, Vol. 10, No. 5, 01.10.2009, p. 407-417.

Research output: Contribution to journalReview article

Emami, CN, Petrosyan, M, Giuliani, S, Williams, M, Hunter, C, Prasadarao, NV & Ford, H 2009, 'Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis', Surgical Infections, vol. 10, no. 5, pp. 407-417. https://doi.org/10.1089/sur.2009.054
Emami, Claudia N. ; Petrosyan, Mikael ; Giuliani, Stefano ; Williams, Monica ; Hunter, Catherine ; Prasadarao, Nemani V. ; Ford, Henri. / Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis. In: Surgical Infections. 2009 ; Vol. 10, No. 5. pp. 407-417.
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AU - Prasadarao, Nemani V.

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