Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer

Xiuhua Gao, Zafar Nawaz

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Progesterone, an ovarian steroid hormone, plays a key role in the development and function of the mammary gland, as it also does in the uterus and the ovary. The action of progesterone is mediated through its intracellular cognate receptor, the progesterone receptor (PR), which functions as a transcription factor that regulates gene expression. As with other nuclear receptors, coregulators (coactivators and corepressors) recruited by the liganded or unliganded PR, either to enhance or to suppress transcription activity, modulate the function of the PR. Mutation or aberrant expression of the coregulators might thus affect the normal function of the PR and hence disrupt the normal development of the mammary gland, which may lead to breast cancer.

Original languageEnglish (US)
Pages (from-to)182-186
Number of pages5
JournalBreast Cancer Research
Volume4
Issue number5
DOIs
StatePublished - Sep 2 2002
Externally publishedYes

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Keywords

  • Breast cancer
  • Coactivator
  • Corepressor
  • Progesterone receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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