Role of Sirtuin 1 in metabolic regulation

Jose P. Silva, Claes R Wahlestedt

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Sirtuin proteins are an evolutionarily conserved family of NAD+-dependent protein deacetylases. Originally discovered in yeast as gene-silencing proteins, they subsequently emerged as key regulators of life span in yeast and other lower species. Recent identification and characterization of mammalian Sirtuin homologs have revealed a widespread spectrum of biological activities in gene regulation linked to cell survival, cell apoptosis and metabolism. These findings have stimulated several drug discovery efforts. Here, we review current knowledge of the biological functions and possible pharmacological implications of Sirtuin 1, the most characterized member of the mammalian Sirtuin family, in glucose and fat metabolism.

Original languageEnglish
Pages (from-to)781-791
Number of pages11
JournalDrug Discovery Today
Volume15
Issue number17-18
DOIs
StatePublished - Sep 1 2010
Externally publishedYes

Fingerprint

Sirtuin 1
Yeasts
Proteins
Gene Silencing
Drug Discovery
NAD
Cell Survival
Fats
Pharmacology
Apoptosis
Glucose
Genes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Role of Sirtuin 1 in metabolic regulation. / Silva, Jose P.; Wahlestedt, Claes R.

In: Drug Discovery Today, Vol. 15, No. 17-18, 01.09.2010, p. 781-791.

Research output: Contribution to journalArticle

Silva, Jose P. ; Wahlestedt, Claes R. / Role of Sirtuin 1 in metabolic regulation. In: Drug Discovery Today. 2010 ; Vol. 15, No. 17-18. pp. 781-791.
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