Role of self and foreign antigenic determinants in allogeneic and self-restricted cytotoxic T cell recognition

R. B. Levy, P. E. Gilheany, G. M. Shearer

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Murine spleen cells were sensitized in vitro to H-2 disparate allogeneic spleen cells and assayed on syngeneic target cells conjugated with the trinitrophenyl (TNP)-self or the fluorescein isothiocyanate (FITC)-self haptens, or on syngeneic target cells expressing the male H-Y antigen (H-Y self). The results indicated that allo-induced cytotoxic T lymphocytes (CTL) contained effectors that lysed both hapten-self but not H-Y-self targets. Furthermore, it was demonstrated that separate populations of these allogeneic CTL were responsible for the lysis of TNP-self and FITC-self targets. This study also showed that cytotoxic effectors generated against the H-Y antigen with lytic activity equal to or greater than that of an allogeneically induced CTL response were unable to lyse hapten-self targets. These findings provide the first evidence that H-2 alloantigens may be unique in their ability to induce effectors that lyse hapten-conjugated autologous targets. These observations are discussed with respect to the self and foreign antigenic determinants involved in allogeneic and self-restricted CTL models.

Original languageEnglish (US)
Pages (from-to)405-418
Number of pages14
JournalJournal of Experimental Medicine
Volume152
Issue number2
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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