Role of platelets in neuroinflammation: A wide-angle perspective

Lawrence L. Horstman, Wenche Jy, Yeon S. Ahn, Robert Zivadinov, Amir H. Maghzi, Masoud Etemadifar, J. Steven Alexander, Alireza Minagar

Research output: Contribution to journalReview article

62 Scopus citations

Abstract

Objectives: This review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the "Poster Child" of these disorders but the implications are wide. The role of platelets in inflammation is well appreciated in the cardiovascular and cancer research communities but appears to be relatively neglected in neurological research.Organization: After a brief introduction to platelets, topics covered include the matrix metalloproteinases, platelet chemokines, cytokines and growth factors, the recent finding of platelet PPAR receptors and Toll-like receptors, complement, bioactive lipids, and other agents/functions likely to be relevant in neuroinflammatory diseases. Each section cites literature linking the topic to areas of active research in MS or other disorders, including especially Alzheimer's disease.Conclusion: The final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research.

Original languageEnglish (US)
Article number10
JournalJournal of Neuroinflammation
Volume7
DOIs
StatePublished - Feb 3 2010

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

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    Horstman, L. L., Jy, W., Ahn, Y. S., Zivadinov, R., Maghzi, A. H., Etemadifar, M., Steven Alexander, J., & Minagar, A. (2010). Role of platelets in neuroinflammation: A wide-angle perspective. Journal of Neuroinflammation, 7, [10]. https://doi.org/10.1186/1742-2094-7-10