ROLE OF PINEAL GLAND IN ÆTIOLOGY AND TREATMENT OF BREAST CANCER

Michael Cohen, Marc E Lippman, Bruce Chabner

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

The hypothesis that diminished function of the pineal gland may promote the development of breast cancer in human beings is suggested by the relation between breast cancer and prolonged œstrogen excess, and by the observation that the pineal secretion, melatonin, inhibits ovarian œstrogen production, pituitary gonadotrophin production, and sexual development and maturation. The hypothesis is supported by the following points. (1) Pineal calcification is commonest in countries with high rates of breast cancer and lowest in areas with a low incidence; the incidences of pineal calcification and of breast cancer are moderate among the black population in the United States. (2) Chlorpromazine raises serum-melatonin; there are reports that psychiatric patients taking chlorpromazine have a lower incidence of breast cancer. (3) Although information is lacking on breast cancer, the pineal and melatonin may influence tumour induction and growth in experimental animals. (4) The demonstration of a melatonin receptor in human ovary suggests a direct influence of this hormone on the ovarian function, and possibly œstrogen production. (5) Impaired pineal secretion is believed to be an important factor triggering puberty (early menarche is a risk factor for breast cancer).

Original languageEnglish
Pages (from-to)814-816
Number of pages3
JournalThe Lancet
Volume312
Issue number8094
DOIs
StatePublished - Oct 14 1978
Externally publishedYes

Fingerprint

Pineal Gland
Breast Neoplasms
Melatonin
Chlorpromazine
Therapeutics
Incidence
Melatonin Receptors
Pituitary Gonadotropins
Sexual Maturation
Sexual Development
Menarche
Puberty
Psychiatry
Ovary
Hormones
Growth
Serum
Population
IDS 89 Sabal serrulata extract
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

ROLE OF PINEAL GLAND IN ÆTIOLOGY AND TREATMENT OF BREAST CANCER. / Cohen, Michael; Lippman, Marc E; Chabner, Bruce.

In: The Lancet, Vol. 312, No. 8094, 14.10.1978, p. 814-816.

Research output: Contribution to journalArticle

Cohen, M, Lippman, ME & Chabner, B 1978, 'ROLE OF PINEAL GLAND IN ÆTIOLOGY AND TREATMENT OF BREAST CANCER', The Lancet, vol. 312, no. 8094, pp. 814-816. https://doi.org/10.1016/S0140-6736(78)92591-6
Cohen, Michael ; Lippman, Marc E ; Chabner, Bruce. / ROLE OF PINEAL GLAND IN ÆTIOLOGY AND TREATMENT OF BREAST CANCER. In: The Lancet. 1978 ; Vol. 312, No. 8094. pp. 814-816.
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