TY - JOUR
T1 - Role of Optic Nerve Imaging in Glaucoma Clinical Practice and Clinical Trials
AU - Greenfield, David S.
AU - Weinreb, Robert N.
N1 - Funding Information:
This study was supported in part by Grants R01-EY013516 and R01-EY08684 from the National Institutes of Health, Bethesda, Maryland, and the Maltz Family Endowment for Glaucoma Research, Cleveland, Ohio. The authors indicate no financial conflict of interest. Dr Greenfield has received research support and has served as a consultant for Carl Zeiss Meditec, Heidelberg Engineering, and Optivue. Dr Weinreb has received research support from Heidelberg Engineering, Carl Zeiss Meditec, Nidek, and Optivue and has served as a consultant for Carl Zeiss Meditec. Both authors were involved in the design and conduct of study; collection and management of data; analysis and interpretation of data; and preparation, review, and approval of the manuscript. This study was performed with adherence to the Declaration of Helsinki and all federal and state laws.
PY - 2008/4
Y1 - 2008/4
N2 - Purpose: To provide an update on the role of optic nerve and peripapillary retinal nerve fiber layer imaging in glaucoma clinical practice and clinical trials. Design: Perspective. Methods: Review of recent literature and authors' clinical and laboratory studies. Results: Imaging technologies such as confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and optical coherence tomography provide objective and quantitative measurements that are highly reproducible and show very good agreement with clinical estimates of optic nerve head structure and visual function. Structural assessments provided by imaging complement optic disk photography in clinical care and have the potential to identify relevant structural efficacy endpoints in glaucoma randomized clinical trials. As with other technologies, imaging may produce false identification of glaucoma and its progression; thus, clinicians should not make management decisions based solely on the results of one single test or technology. Conclusions: Although optic disk stereophotography represents the standard for documentation of glaucomatous structural damage in practice and research trials, advances in computerized imaging technology provide useful measures that assist the clinician in glaucoma diagnosis and monitoring and offer considerable opportunity for use as efficacy endpoints in clinical trials.
AB - Purpose: To provide an update on the role of optic nerve and peripapillary retinal nerve fiber layer imaging in glaucoma clinical practice and clinical trials. Design: Perspective. Methods: Review of recent literature and authors' clinical and laboratory studies. Results: Imaging technologies such as confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and optical coherence tomography provide objective and quantitative measurements that are highly reproducible and show very good agreement with clinical estimates of optic nerve head structure and visual function. Structural assessments provided by imaging complement optic disk photography in clinical care and have the potential to identify relevant structural efficacy endpoints in glaucoma randomized clinical trials. As with other technologies, imaging may produce false identification of glaucoma and its progression; thus, clinicians should not make management decisions based solely on the results of one single test or technology. Conclusions: Although optic disk stereophotography represents the standard for documentation of glaucomatous structural damage in practice and research trials, advances in computerized imaging technology provide useful measures that assist the clinician in glaucoma diagnosis and monitoring and offer considerable opportunity for use as efficacy endpoints in clinical trials.
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U2 - 10.1016/j.ajo.2007.12.018
DO - 10.1016/j.ajo.2007.12.018
M3 - Article
C2 - 18295183
AN - SCOPUS:40849130823
VL - 145
SP - 598-603.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 4
ER -