Role of norepinephrine in the pathophysiology of neuropsychiatric disorders

Kerry J. Ressler, Charles Nemeroff

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The concatenation of convergent lines of evidence from basic to clinical research continues to reveal that norepinephrine (NE) is a crucial regulator of a myriad of behaviors ranging from stress response to memory formation. Furthermore, many neuropsychiatric disorders involve neuro-circuitry that is directly modulated by NE. This report summarizes the physiological roles of NE, as well as the main findings implicating a role for NE system dysfunction in mood and anxiety disorders, posttraumatic stress disorder, attention-deficit/hyperactivity disorder, and Alzheimer's disease. In each of these disorders, there appears to be a complex dysregulation of NE function, with changes in locus ceruleus firing, NE availability, and both pre- and postsynaptic receptor regulation. Many symptoms of these disorders are attributable to abnormalities within distributed neural circuits regulated by NE. Appreciation of NE's role in modulating the neural circuitry mediating cognition and affect should help elucidate the pathophysiology of a variety of neuropsychiatric disorders and the development of novel treatments.

Original languageEnglish
Pages (from-to)663-670
Number of pages8
JournalCNS Spectrums
Volume6
Issue number8
StatePublished - Dec 1 2001
Externally publishedYes

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Norepinephrine
Presynaptic Receptors
Locus Coeruleus
Attention Deficit Disorder with Hyperactivity
Post-Traumatic Stress Disorders
Anxiety Disorders
Mood Disorders
Cognition
Alzheimer Disease
Research

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Role of norepinephrine in the pathophysiology of neuropsychiatric disorders. / Ressler, Kerry J.; Nemeroff, Charles.

In: CNS Spectrums, Vol. 6, No. 8, 01.12.2001, p. 663-670.

Research output: Contribution to journalArticle

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