Role of nitric oxide in the pathophysiology of heart failure

Hunter C. Champion, Michel W. Skaf, Joshua Hare

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Nitric oxide (NO) plays critical roles in the regulation of integrated cardiac and vascular function and homeostasis. An understanding of the physiologic role and relative contribution of the three NO synthase isoforms (neuronal-NOS1, inducible-NOS2, and endothelial-NOS3) is imperative to comprehend derangements of the NO signaling pathway in the failing cardiovascular system. Several theories of NO and its regulation have developed as explanations for the divergent observations from studies in health and disease states. Here we review the physiologic and pathophysiologic influence of NO on cardiac function, in a framework that considers several theories of altered NO signaling in heart failure. We discuss the notion of spatial compartmentalization of NO signaling within the myocyte in an effort to reconcile many controversies about derangements in the influences of NO in the heart and vasculature.

Original languageEnglish
Pages (from-to)35-46
Number of pages12
JournalHeart Failure Reviews
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Nitric Oxide
Heart Failure
Nitric Oxide Synthase Type I
Cardiovascular System
Muscle Cells
Blood Vessels
Protein Isoforms
Homeostasis
Health

Keywords

  • Heart failure
  • Myocyte
  • Nitric oxide
  • Spatial compartmentalization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Role of nitric oxide in the pathophysiology of heart failure. / Champion, Hunter C.; Skaf, Michel W.; Hare, Joshua.

In: Heart Failure Reviews, Vol. 8, No. 1, 01.01.2003, p. 35-46.

Research output: Contribution to journalArticle

Champion, Hunter C. ; Skaf, Michel W. ; Hare, Joshua. / Role of nitric oxide in the pathophysiology of heart failure. In: Heart Failure Reviews. 2003 ; Vol. 8, No. 1. pp. 35-46.
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