Role of nitric oxide in the pathophysiology of heart failure

Hunter C. Champion, Michel W. Skaf, Joshua M. Hare

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Nitric oxide (NO) plays critical roles in the regulation of integrated cardiac and vascular function and homeostasis. An understanding of the physiologic role and relative contribution of the three NO synthase isoforms (neuronal-NOS1, inducible-NOS2, and endothelial-NOS3) is imperative to comprehend derangements of the NO signaling pathway in the failing cardiovascular system. Several theories of NO and its regulation have developed as explanations for the divergent observations from studies in health and disease states. Here we review the physiologic and pathophysiologic influence of NO on cardiac function, in a framework that considers several theories of altered NO signaling in heart failure. We discuss the notion of spatial compartmentalization of NO signaling within the myocyte in an effort to reconcile many controversies about derangements in the influences of NO in the heart and vasculature.

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalHeart Failure Reviews
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • Heart failure
  • Myocyte
  • Nitric oxide
  • Spatial compartmentalization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Role of nitric oxide in the pathophysiology of heart failure'. Together they form a unique fingerprint.

  • Cite this