Role of neurotrophins in the development and plasticity of the visual system

Experiments on dark rearing

Tommaso Pizzorusso, Michela Fagiolini, Laura Gianfranceschi, Vittorio Porciatti, Lamberto Maffei

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

An extensive series of studies, beginning with the pioneering experiments of Wiesel and Hubel, have shown that correct visual experience is crucial for the development of the visual system. Several years ago, we put forward the hypothesis that neurotrophic factors of the neurotrophin family (NGF, BDNF, NT-3, NT-4) have a role in mediating the effects of visual experience in the developing visual system. This theory is based on the following experimental results: (a) exogenous supply of neurotrophins during the critical period prevents the effects of monocular deprivation; and (b) transplant of cells releasing NGF allows a normal development of the functional properties of visual cortical neurons in dark-reared rats. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalInternational Journal of Psychophysiology
Volume35
Issue number2-3
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

Fingerprint

Nerve Growth Factors
Nerve Growth Factor
Brain-Derived Neurotrophic Factor
Transplants
Neurons

Keywords

  • NGF
  • Visual cortex
  • Visual deprivation

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Role of neurotrophins in the development and plasticity of the visual system : Experiments on dark rearing. / Pizzorusso, Tommaso; Fagiolini, Michela; Gianfranceschi, Laura; Porciatti, Vittorio; Maffei, Lamberto.

In: International Journal of Psychophysiology, Vol. 35, No. 2-3, 01.03.2000, p. 189-196.

Research output: Contribution to journalArticle

Pizzorusso, Tommaso ; Fagiolini, Michela ; Gianfranceschi, Laura ; Porciatti, Vittorio ; Maffei, Lamberto. / Role of neurotrophins in the development and plasticity of the visual system : Experiments on dark rearing. In: International Journal of Psychophysiology. 2000 ; Vol. 35, No. 2-3. pp. 189-196.
@article{9052ea41a0f94337bd1c876585ae9eaf,
title = "Role of neurotrophins in the development and plasticity of the visual system: Experiments on dark rearing",
abstract = "An extensive series of studies, beginning with the pioneering experiments of Wiesel and Hubel, have shown that correct visual experience is crucial for the development of the visual system. Several years ago, we put forward the hypothesis that neurotrophic factors of the neurotrophin family (NGF, BDNF, NT-3, NT-4) have a role in mediating the effects of visual experience in the developing visual system. This theory is based on the following experimental results: (a) exogenous supply of neurotrophins during the critical period prevents the effects of monocular deprivation; and (b) transplant of cells releasing NGF allows a normal development of the functional properties of visual cortical neurons in dark-reared rats. Copyright (C) 2000 Elsevier Science B.V.",
keywords = "NGF, Visual cortex, Visual deprivation",
author = "Tommaso Pizzorusso and Michela Fagiolini and Laura Gianfranceschi and Vittorio Porciatti and Lamberto Maffei",
year = "2000",
month = "3",
day = "1",
doi = "10.1016/S0167-8760(99)00053-7",
language = "English",
volume = "35",
pages = "189--196",
journal = "International Journal of Psychophysiology",
issn = "0167-8760",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Role of neurotrophins in the development and plasticity of the visual system

T2 - Experiments on dark rearing

AU - Pizzorusso, Tommaso

AU - Fagiolini, Michela

AU - Gianfranceschi, Laura

AU - Porciatti, Vittorio

AU - Maffei, Lamberto

PY - 2000/3/1

Y1 - 2000/3/1

N2 - An extensive series of studies, beginning with the pioneering experiments of Wiesel and Hubel, have shown that correct visual experience is crucial for the development of the visual system. Several years ago, we put forward the hypothesis that neurotrophic factors of the neurotrophin family (NGF, BDNF, NT-3, NT-4) have a role in mediating the effects of visual experience in the developing visual system. This theory is based on the following experimental results: (a) exogenous supply of neurotrophins during the critical period prevents the effects of monocular deprivation; and (b) transplant of cells releasing NGF allows a normal development of the functional properties of visual cortical neurons in dark-reared rats. Copyright (C) 2000 Elsevier Science B.V.

AB - An extensive series of studies, beginning with the pioneering experiments of Wiesel and Hubel, have shown that correct visual experience is crucial for the development of the visual system. Several years ago, we put forward the hypothesis that neurotrophic factors of the neurotrophin family (NGF, BDNF, NT-3, NT-4) have a role in mediating the effects of visual experience in the developing visual system. This theory is based on the following experimental results: (a) exogenous supply of neurotrophins during the critical period prevents the effects of monocular deprivation; and (b) transplant of cells releasing NGF allows a normal development of the functional properties of visual cortical neurons in dark-reared rats. Copyright (C) 2000 Elsevier Science B.V.

KW - NGF

KW - Visual cortex

KW - Visual deprivation

UR - http://www.scopus.com/inward/record.url?scp=0033975266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033975266&partnerID=8YFLogxK

U2 - 10.1016/S0167-8760(99)00053-7

DO - 10.1016/S0167-8760(99)00053-7

M3 - Article

VL - 35

SP - 189

EP - 196

JO - International Journal of Psychophysiology

JF - International Journal of Psychophysiology

SN - 0167-8760

IS - 2-3

ER -