Role of neurotrophins in the development and plasticity of the visual system: Experiments on dark rearing

Tommaso Pizzorusso, Michela Fagiolini, Laura Gianfranceschi, Vittorio Porciatti, Lamberto Maffei

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

An extensive series of studies, beginning with the pioneering experiments of Wiesel and Hubel, have shown that correct visual experience is crucial for the development of the visual system. Several years ago, we put forward the hypothesis that neurotrophic factors of the neurotrophin family (NGF, BDNF, NT-3, NT-4) have a role in mediating the effects of visual experience in the developing visual system. This theory is based on the following experimental results: (a) exogenous supply of neurotrophins during the critical period prevents the effects of monocular deprivation; and (b) transplant of cells releasing NGF allows a normal development of the functional properties of visual cortical neurons in dark-reared rats. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalInternational Journal of Psychophysiology
Volume35
Issue number2-3
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

Keywords

  • NGF
  • Visual cortex
  • Visual deprivation

ASJC Scopus subject areas

  • Behavioral Neuroscience

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