Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma

Armin Braun, Elena Appel, Rina Baruch, Udo Herz, Vladimir Botchkarev, Ralf Paus, Chaya Brodie, Harald Renz

Research output: Contribution to journalArticle

231 Scopus citations

Abstract

The role of nerve growth factor (NGF), a potent mediator acting in the development and differentitation of both neuronal and immune cells, was examined in a mouse model of allergic asthma. NGF-positive cells were detected in the inflammatory infiltrate of the lung and enhanced levels of NGF were detected in serum and broncho-alveolar lavage fluids. Mononuclear cells in inflamed airway mucosa as well as broncho-alveolar macrophages were identified as one source of NGF production. Splenic mononuclear cells from allergen-sensitized mice produced NGF in response to allergen. They responded to exogenously added NGF with a dose-dependent increase in IL-4 and IL-5 production and augmented IgE and IgG1 synthesis. In contrast, IFN-γ, and IgG(2a) levels remained unaffected. The effects were NGF specific, since they could be blocked by an anti-NGF-antibody. Nasal application of anti-NGF to allergen-sensitized mice significantly reduced IL-4 and prevented development of airway hyperreactivity. These results show that allergic airway inflammation is accompanied by enhanced local NGF production that acts as an amplifier for Th2 effector functions and plays an important role in the development of airway hyperreactivity. Therefore it is suggested that NGF may serve as a link between the immune and nerve system.

Original languageEnglish (US)
Pages (from-to)3240-3251
Number of pages12
JournalEuropean Journal of Immunology
Volume28
Issue number10
DOIs
StatePublished - Oct 1 1998
Externally publishedYes

Keywords

  • Airway hyperreactivity
  • Allergy
  • Mouse
  • Neurotrophin
  • Th2 immune response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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