Role of myelin-associated inhibitors in axonal repair after spinal cord injury

Jae K. Lee, Binhai Zheng

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research. A myriad of experimental approaches have been applied to investigate the potential of targeting these molecules to promote axonal repair after spinal cord injury. However, there are still conflicting results on their role in axon regeneration and therefore a lack of a cohesive mechanism on how these molecules can be targeted to promote axon repair. One major reason may be the lack of a clear definition of axon regeneration in the first place. Nevertheless, recent data from genetic studies in mice indicate that the roles of these molecules in CNS axon repair may be more intricate than previously envisioned.

Original languageEnglish (US)
Pages (from-to)33-42
Number of pages10
JournalExperimental neurology
Issue number1
StatePublished - May 2012


  • Axon regeneration
  • MAG
  • Myelin
  • NgR1
  • Nogo
  • Nogo receptor
  • OMgp
  • Spinal cord injury
  • Sprouting

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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