Role of Matricellular Proteins in Disorders of the Central Nervous System

A. R. Jayakumar, A. Apeksha, Michael D Norenberg

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Matricellular proteins (MCPs) are actively expressed non-structural proteins present in the extracellular matrix, which rapidly turnover and possess regulatory roles, as well as mediate cell–cell interactions. MCPs characteristically contain binding sites for other extracellular proteins, cell surface receptors, growth factors, cytokines and proteases, that provide structural support for surrounding cells. MCPs are present in most organs, including brain, and play a major role in cell–cell interactions and tissue repair. Among the MCPs found in brain include thrombospondin-1/2, secreted protein acidic and rich in cysteine family (SPARC), including Hevin/SC1, Tenascin C and CYR61/Connective Tissue Growth Factor/Nov family of proteins, glypicans, galectins, plasminogen activator inhibitor (PAI-1), autotaxin, fibulin and perisostin. This review summarizes the potential role of MCPs in the pathogenesis of major neurological disorders, including Alzheimer’s disease, amyotrophic lateral sclerosis, ischemia, trauma, hepatic encephalopathy, Down’s syndrome, autism, multiple sclerosis, brain neoplasms, Parkinson’s disease and epilepsy. Potential therapeutic opportunities of MCP’s for these disorders are also considered in this review.

Original languageEnglish (US)
Pages (from-to)1-18
Number of pages18
JournalNeurochemical Research
DOIs
StateAccepted/In press - Nov 23 2016

Fingerprint

Central Nervous System Diseases
Neurology
Proteins
Brain
Plasminogen Activator Inhibitor 1
Glypicans
Galectins
Thrombospondin 1
Connective Tissue Growth Factor
Tenascin
Plasminogen Inactivators
Cell Surface Receptors
Hepatic Encephalopathy
Amyotrophic Lateral Sclerosis
Autistic Disorder
Down Syndrome
Nervous System Diseases
Cysteine
Brain Neoplasms
Intercellular Signaling Peptides and Proteins

Keywords

  • Astrocytes
  • Cell–cell interaction
  • Matricellular proteins
  • Neurological disorders

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Role of Matricellular Proteins in Disorders of the Central Nervous System. / Jayakumar, A. R.; Apeksha, A.; Norenberg, Michael D.

In: Neurochemical Research, 23.11.2016, p. 1-18.

Research output: Contribution to journalArticle

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