Role of hypothalamic-pituitary axis in morphine-induced alteration in thymic cell distribution using mu-opioid receptor knockout mice

Sabita Roy, Jing Hua Wang, Sudha Balasubramanian, Sumandeep, Rick Charboneau, Roderick Barke, Horace H. Loh

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Mu-opioid receptor knockout mice (MORKO), were used to address two questions: (1) if morphine induced decrease in thymic weight and cell distribution is mediated by the mu-opioid receptor and (2) the role of corticosteroids in morphine mediated alteration in thymic cell distribution. Our result show that morphine mediated increase in plasma corticosterone is mediated by the mu-opioid receptor since morphine at doses as high as 25 mg/kg-body weight does not increase plasma corticosterone levels in the MORKO. In addition, we have also shown that morphine treatment results in the differentiation of CD4 + CD8 + (double positive cells) to single positive CD4 + cells while dexamethasone treatment results in the deletion of CD4 + CD8 + (double positive) cells.

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalJournal of Neuroimmunology
Volume116
Issue number2
DOIs
StatePublished - Jun 1 2001

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Keywords

  • Corticosterone
  • Dexamethasone
  • Morphine
  • Mu-opioid receptor knockout
  • T cell
  • Thymus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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