Role of GTPases in Driving Mitoribosome Assembly

Priyanka Maiti, Elena Lavdovskaia, Antoni Barrientos, Ricarda Richter-Dennerlein

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant class. Here, we review recent progress in our understanding of mitoribosome assembly GTPases. We describe their shared and specific features and mechanisms of action, compare them with their bacterial counterparts, and discuss their possible roles in the assembly of small or large mitoribosomal subunits and the formation of the monosome by establishing quality-control checkpoints during these processes. Furthermore, following the recent unification of the nomenclature for the mitoribosomal proteins, we also propose a unified nomenclature for mitoribosome assembly GTPases.

Original languageEnglish (US)
Pages (from-to)284-297
Number of pages14
JournalTrends in Cell Biology
Volume31
Issue number4
DOIs
StatePublished - Apr 2021
Externally publishedYes

Keywords

  • GTPBP
  • OXPHOS deficiency
  • mitochondrial diseases
  • mitochondrial ribosome
  • mitoribosome assembly GTPase
  • quality control of mitoribosome maturation

ASJC Scopus subject areas

  • Cell Biology

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