TY - JOUR
T1 - Role of glycans and glycoproteins in disease development by Mycobacterium tuberculosis
AU - Sonawane, Avinash
AU - Mohanty, Soumitra
AU - Jagannathan, Lakshmanan
AU - Bekolay, Ashley
AU - Banerjee, Sulagna
N1 - Funding Information:
The authors would like to thank Prof. Peter Leuthy and the lab members for critical review of the manuscript. This work was supported by a grant from Indian Medical Research Council, Government of India to AS.
PY - 2012/8
Y1 - 2012/8
N2 - Glycoproteins play a critical role in hostpathogen interactions, antigenicity, and virulence determination, and are therefore, considered as potential drug targets. The cell wall of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), dominantly contains sugars and lipids. Despite the efforts taken by the World Health Organization to reduce the incidence rate, the prevalence of TB is increasing in certain regions. This is mainly attributed to the emergence of multidrug-resistant bacteria. Factors that contribute to Mtb virulence and antigenicity remain elusive. However, several studies have shown that sugars and lipids are mainly responsible for Mtb pathogenesis and resistance to numerous drugs. This review gives insight into the role of glycoproteins in mycobacterium pathogenesis, disease development, and its implications in drug development.
AB - Glycoproteins play a critical role in hostpathogen interactions, antigenicity, and virulence determination, and are therefore, considered as potential drug targets. The cell wall of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), dominantly contains sugars and lipids. Despite the efforts taken by the World Health Organization to reduce the incidence rate, the prevalence of TB is increasing in certain regions. This is mainly attributed to the emergence of multidrug-resistant bacteria. Factors that contribute to Mtb virulence and antigenicity remain elusive. However, several studies have shown that sugars and lipids are mainly responsible for Mtb pathogenesis and resistance to numerous drugs. This review gives insight into the role of glycoproteins in mycobacterium pathogenesis, disease development, and its implications in drug development.
KW - Drug target
KW - Glycoproteins
KW - Mycobacteria
KW - Pathogenesis
KW - Tuberculosis
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U2 - 10.3109/1040841X.2011.653550
DO - 10.3109/1040841X.2011.653550
M3 - Review article
C2 - 22324751
AN - SCOPUS:84863454427
VL - 38
SP - 250
EP - 266
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
SN - 1040-841X
IS - 3
ER -