Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome and diabetes

B. Sears, Camillo Ricordi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Obesity, metabolic syndrome and diabetes represent multi-Factorial conditions resulting from improper balances of hormones and gene expression. In addition, these conditions have a strong inflammatory component that can potentially be impacted by the diet. The purpose of this review is to discuss the molecular targets that can be addressed by anti-Inflammatory nutrition. These molecular targets range from reduction of pro-Inflammatory eicosanoids that can alter hormonal signaling cascades to the modulation of the innate immune system, via toll-Like receptors and gene transcription factors. Working knowledge of the impact of nutrients, especially dietary fatty acids and polyphenols, on these various molecular targets makes it possible to develop a general outline of an anti-Inflammatory diet that offers a unique, non-Pharmacological approach for treating obesity, metabolic syndrome and diabetes.

Original languageEnglish
Pages (from-to)1137-1154
Number of pages18
JournalEuropean Review for Medical and Pharmacological Sciences
Volume16
Issue number9
StatePublished - Sep 1 2012

Fingerprint

Polyphenols
Anti-Inflammatory Agents
Fatty Acids
Obesity
Diet
Eicosanoids
Toll-Like Receptors
Genes
Immune System
Transcription Factors
Hormones
Gene Expression
Food

Keywords

  • Diabetes
  • Fatty acids
  • Inflammatory gene transcription
  • Metabolic syndrome
  • Obesity
  • Polyphenols

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

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