Role of farnesyltransferase inhibitors in hematologic malignancies

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The treatment of hematologic malignancies has progressed in the last few years. Identification of new pathways and target molecules in leukemia has ushered in a promising new era of therapy. Ras mutations have recently been implicated in the pathogenesis of acute leukemia, and inhibition of Ras signaling through the use of farnesyltransferase inhibitors (FTIs) has shown promise in early trials in acute myeloid leukemia (AML). Responses have not correlated with the presence of Ras mutations, suggesting that novel pathways are involved. In several early trials, FTIs have shown activity as single agents in poor-risk AML, suggesting a potential role in combination with standard chemotherapy. FTIs are now being tested in other clinical settings, such as myelodysplasia, chronic myelogenous leukemia and multiple myeloma, with encouraging preliminary activity.

Original languageEnglish (US)
Pages (from-to)843-856
Number of pages14
JournalExpert review of anticancer therapy
Volume4
Issue number5
DOIs
StatePublished - Oct 2004

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Keywords

  • BMS-214662
  • Farnesyltransferase inhibitor
  • Lonafarnib
  • Mitogen-activated protein kinase
  • Myelodysplasia
  • Myelofibrosis
  • Myeloid leukemia
  • Ras mutation
  • RhoB protein
  • Tipifarnib

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research

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