Role of endotoxin and bacteria in long-term survival of preserved small-bowel allografts

Luis H. Toledo-Pereyra, Leopoldo Raij, Richard L. Simmons, John S. Najarian

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Endotoxins are potent immunological adjuvants that can accelerate the death of unprepared canine small bowels perfused for 12 hours and then allotransplanted. Hemorrhagic necrosis was a consistent finding in the endotoxin-positive dogs. This represented either an accelerated type of rejection or intravascular coagulation-like phenomenon. The preparation of the small bowel with antibiotics led to prolongation of survival.

Original languageEnglish (US)
Pages (from-to)474-481
Number of pages8
JournalSurgery
Volume76
Issue number3
StatePublished - Sep 1974

ASJC Scopus subject areas

  • Surgery

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