Role of endotoxin and bacteria in long-term survival of preserved small-bowel allografts

Luis H. Toledo-Pereyra, Leopoldo Raij, Richard L. Simmons, John S. Najarian

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Endotoxins are potent immunological adjuvants that can accelerate the death of unprepared canine small bowels perfused for 12 hours and then allotransplanted. Hemorrhagic necrosis was a consistent finding in the endotoxin-positive dogs. This represented either an accelerated type of rejection or intravascular coagulation-like phenomenon. The preparation of the small bowel with antibiotics led to prolongation of survival.

Original languageEnglish (US)
Pages (from-to)474-481
Number of pages8
JournalSurgery
Volume76
Issue number3
StatePublished - Sep 1974

ASJC Scopus subject areas

  • Surgery

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    Toledo-Pereyra, L. H., Raij, L., Simmons, R. L., & Najarian, J. S. (1974). Role of endotoxin and bacteria in long-term survival of preserved small-bowel allografts. Surgery, 76(3), 474-481.