Role of cytokines in the pathogenesis of acute and chronic kidney disease, glomerulonephritis, and end-stage kidney disease

Luis M. Ortega, Alessia Fornoni

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Cytokines are soluble mediators that are released from sites of local injury exposed to an inflammatory environment. In kidney diseases, cytokines can be released by circulating leukocytes and/or from activated or injured kidney cells, which in turn attract and activate leukocytes to specific sites of injury. Therefore, cytokines may act in a systemic, paracrine, or an autocrine fashion. Different patterns of pro-inflammatory and anti-inflammatory cytokines expression and activation characterize acute kidney injury (AKI), glomerulonephritis (GMN), and end-stage kidney disease (ESKD). Moreover, plasma levels of certain cytokines and gene polymorphisms for certain cytokines may have predictive value in these different clinical scenarios. The present review will compile information regarding the role of different types of cytokines in the pathogenesis of AKI, GMN, and ESKD. Both clinical data and experimental models of injury will be discussed.

Original languageEnglish (US)
Pages (from-to)49-62
Number of pages14
JournalInternational Journal of Interferon, Cytokine and Mediator Research
Volume2
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Acute kidney injury
  • Cytokines
  • End-stage kidney disease
  • Glomerulonephritis
  • Hemodialysis
  • Inflammation
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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