Role of cholecystokinin, gastrin and gastrin-releasing peptide in the regulation of pancreatic secretion in cats

Slanislaw J. Konturek, Jan Bilski, Mariusz Hladij, Eugeniusz Krzyzek, Renzhi Cai, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

This study performed on 6 conscious cats with chronic pancreatic fistulas was designed to determine the role of cholecystokinin (CCK), gastrin and gastrin-releasing peptide (GRP) in stimulation of pancreatic secretion in this species. Pancreatic response to GRP infused intravenously in graded doses appears to be mediated predominantly by CCK because a CCK receptor antagonist, L-364,718, abolished this response. Also, gastrin appears to mediate in part the secretory response to GRP because blockade of gastrin receptors by L-365, 260, given at the dose that completely abolished the pancreatic response to exogenous gastrin, caused a significant reduction in the bombesin-induced pancreatic secretion. CCK and partly gastrin appear to mediate the postprandial pancreatic secretion in cats as the administration of L-364,718 and L-365,260 inhibited this secretion by over 90 and 30%, respectively. In contrast, GRP does not seem to contribute to food-induced pancreatic secretory stimulation, because the blockade of GRP receptors using novel bombesin/GRP antagonist (RC-3100) failed to affect this secretion. We conclude that CCK and partly gastrin, but not GRP, play an essential role in the postprandial pancreatic secretion.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalDigestion
Volume49
Issue number2
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • Amylase
  • Antagonists
  • Bombesin
  • Pancreas
  • Peptides
  • Receptors

ASJC Scopus subject areas

  • Gastroenterology

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