Role of Cdc42 dynamics in the control of fission yeast cell polarization

Maitreyi Das; Fulvia Verde

doi:10.1042/BST20130241

Role of Cdc42 dynamics in the control of fission yeast cell polarization

Maitreyi Das, Fulvia Verde

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized cell growth and timedelayed negative feedback, define a cellular-level system that promotes Cdc42 oscillatory dynamics and modulates activated Cdc42 intracellular distribution.

Original language	English (US)
Pages (from-to)	1745-1749
Number of pages	5
Journal	Biochemical Society transactions
Volume	41
Issue number	6
DOIs	https://doi.org/10.1042/BST20130241
State	Published - Dec 2013

Keywords

Cdc42
Cell polarity
Fission yeast
Morphogenesis
Symmetry breaking

ASJC Scopus subject areas

Biochemistry

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AU - Verde, Fulvia

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AB - Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized cell growth and timedelayed negative feedback, define a cellular-level system that promotes Cdc42 oscillatory dynamics and modulates activated Cdc42 intracellular distribution.

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KW - Morphogenesis

KW - Symmetry breaking

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