Role of Cdc42 dynamics in the control of fission yeast cell polarization

Maitreyi Das, Fulvia Verde

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized cell growth and timedelayed negative feedback, define a cellular-level system that promotes Cdc42 oscillatory dynamics and modulates activated Cdc42 intracellular distribution.

Original languageEnglish (US)
Pages (from-to)1745-1749
Number of pages5
JournalBiochemical Society transactions
Volume41
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • Cdc42
  • Cell polarity
  • Fission yeast
  • Morphogenesis
  • Symmetry breaking

ASJC Scopus subject areas

  • Biochemistry

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