Abstract
Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized cell growth and timedelayed negative feedback, define a cellular-level system that promotes Cdc42 oscillatory dynamics and modulates activated Cdc42 intracellular distribution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1745-1749 |
| Number of pages | 5 |
| Journal | Biochemical Society transactions |
| Volume | 41 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2013 |
Keywords
- Cdc42
- Cell polarity
- Fission yeast
- Morphogenesis
- Symmetry breaking
ASJC Scopus subject areas
- Biochemistry