Role of bacterial and viral pathogens in gastric carcinogenesis

Manikandan Palrasu, Elena Zaika, Wael El-Rifai, Jianwen Que, Alexander I. Zaika

Research output: Contribution to journalReview articlepeer-review

Abstract

Gastric cancer (GC) is one of the deadliest malignancies worldwide. In contrast to many other tumor types, gastric carcinogenesis is tightly linked to infectious events. Infections with Helicobacter pylori (H. pylori) bacterium and Epstein–Barr virus (EBV) are the two most investigated risk factors for GC. These pathogens infect more than half of the world’s population. Fortunately, only a small fraction of infected individuals develops GC, suggesting high complexity of tumorigenic processes in the human stomach. Recent studies suggest that the multifaceted interplay between microbial, environmental, and host genetic factors underlies gastric tumorigenesis. Many aspects of these interactions still remain unclear. In this review, we update on recent discoveries, focusing on the roles of various gastric pathogens and gastric microbiome in tumorigenesis.

Original languageEnglish (US)
Article number1878
JournalCancers
Volume13
Issue number8
DOIs
StatePublished - Apr 2 2021

Keywords

  • EBV
  • Gastric pathogens
  • Gastric tumor
  • H. pylori
  • P14ARF
  • P53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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