Role of ATP-sensitive potassium channels in the piracetam induced blockade of opioid effects

Ashish K. Rehni, Nirmal Singh, Seema Jindal

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The present study has been designed to investigate the effect of piracetam on morphine/ buprenorphine-induced antinociception in rats and effect of piracetam on morphine or minoxidil induced relaxation in KCl-precontracted isolated rat aortic ring preparation. Nociceptive threshold was measured by the tail flick test in rats. The cumulative dose responses of morphine or minoxidil were recorded in KCl-precontracted isolated rat aortic ring preparation. Piracetam attenuated buprenorphine-induced antinociception in rats. Piracetam significantly reduced the morphine and minoxidil induced relaxation in KCl precontracted isolated rat aortic ring preparation suggesting that piracetam interferes with opioid receptor and ATP-sensitive potassium channel (K ATP) opener mediated responses in vitro. Thus, it may be suggested that piracetam attenuates opioid effects by an opioid receptor-KATP channel linked mechanism.

Original languageEnglish (US)
Pages (from-to)1050-1054
Number of pages5
JournalIndian Journal of Experimental Biology
Volume45
Issue number12
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • Antinociception
  • ATP-sensitive potassium channels
  • Opioid receptor
  • Piracetam

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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