Role of arachidonic acid metabolites in allergen-induced late responses1

William M. Abraham, André P. Perruchoudh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The sheep model of allergic airway disease shares many pathophysiological similarities with allergic airway disease in humans. Studies performed in this animal model present strong evidence that the release of arachidonic acid metabolites plays an important role in the development of late bronchial responses to antigen challenge. The release of leukotrienes through the lipoxygenase pathway during the acute bronchial obstruction after inhalation of Ascaris suum antigen represents the key factor for the initiation of the subsequent events, namely the late phase response and the bronchial hyperreactivity. If this hypothesis can be substantiated in patients with bronchial asthma then pharmacologic modification of the lipoxygenase pathway and/or products may be important in the treatment of asthma.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
Issue number1-2
StatePublished - 1989


  • Allergen-induced bronchoconstriction
  • Animal models
  • Arachidonic acid metabolites
  • Asthma, bronchial
  • Bronchial responses, late

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine


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